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Infertility and pregnancy outcome in an unselected group of women with insulin-dependent diabetes mellitus

  • Author Footnotes
    1 From the Department of Internal Medicine and Endocrinology, Odense University Hospital.
    Karen Kjaer
    Correspondence
    Reprint requests: Karen Kjaer, MD, Department of Internal Medicine and Endocrinology, Odense University Hospital, 5000 Odense C, Denmark.
    Footnotes
    1 From the Department of Internal Medicine and Endocrinology, Odense University Hospital.
    Affiliations
    Odense, Denmark
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  • Author Footnotes
    1 From the Department of Internal Medicine and Endocrinology, Odense University Hospital.
    Claus Hagen
    Footnotes
    1 From the Department of Internal Medicine and Endocrinology, Odense University Hospital.
    Affiliations
    Odense, Denmark
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  • Author Footnotes
    1 From the Department of Internal Medicine and Endocrinology, Odense University Hospital.
    Steen H. Sandø
    Footnotes
    1 From the Department of Internal Medicine and Endocrinology, Odense University Hospital.
    Affiliations
    Odense, Denmark
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  • Author Footnotes
    1 From the Department of Internal Medicine and Endocrinology, Odense University Hospital.
    Ole Eshøj
    Footnotes
    1 From the Department of Internal Medicine and Endocrinology, Odense University Hospital.
    Affiliations
    Odense, Denmark
    Search for articles by this author
  • Author Footnotes
    1 From the Department of Internal Medicine and Endocrinology, Odense University Hospital.
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      Objective: The null hypothesis of this study Is that Infertility and pregnancy outcomes In women with insulin-dependent diabetes are identical to those of nondiabetic control subjects.
      Study Design: A questionnaire survey comprising an unselected population of 18- to 49-year-old diabetic women and a comparable control group was performed. Reply rates were 94% (n = 245) and 88% (n = 253), respectively.
      Results: Cumulative rates of pregnancies and involuntary infertility (17%) did not differ between the two groups. Diabetic women had significantly fewer pregnancies (1.4 vs 1.7) and fewer births per pregnancy than controls, and more diabetic women were nulliparous (48% vs 38%). Half of all diabetic pregnancies were planned. Diabetic women reported that their diabetes had a negative influence on their attitude toward having children.
      Conclusion: In insulin-dependent diabetic women the ability to conceive is normal, but diabetic women have fewer pregnancies and fewer births per pregnancy than controls.

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