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Changes in human fetal cerebral hemoglobin concentration and oxygenation during labor measured by near-infrared spectroscopy

  • Author Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
    Donald M. Peebles
    Correspondence
    Reprint requests: D.M. Peebles, MB, Department of Pediatrics, UCMSM, Rayne Institute, University St., London, England WC1E 6JJ.
    Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
    Affiliations
    London, England
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  • Author Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
    A. David Edwards
    Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
    Affiliations
    London, England
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  • Author Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
    John S. Wyatt
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    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
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    London, England
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  • Author Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
    Anthony P. Bishop
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    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
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    London, England
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  • Author Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
    Mark Cope
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    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
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    London, England
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  • Author Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
    David T. Delpy
    Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
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    London, England
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  • Author Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
    E. Osmund R. Reynolds
    Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
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    London, England
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  • Author Footnotes
    1 From the Departments of Pediatrics, Obstetrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine.
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      Objective: The purpose of this study was to measure by near-infrared spectroscopy changes in human fetal cerebral oxyhemoglobin, deoxyhemoglobin, and cerebral blood volume during labor and to calculate mean cerebral hemoglobin oxygen saturation.
      Study Design: The effects of uterine contractions with and without fetal heart rate decelerations were compared in eight singleton term fetuses. Results were analyzed by analysis of variance.
      Results: In six of eight fetuses normal uterine contractions were associated with proportional decreases in both oxyhemoglobin and deoxyhemoglobin and a fall in cerebral blood volume without desaturation of cerebral hemoglobin. Contractions with fetal heart rate decelerations produced different results in that oxyhemoglobin fell but deoxyhemoglobin rose, indicating cerebral desaturation. In two of the eight fetuses normal contractions were associated with increases in oxyhemoglobin, deoxyhemoglobin, and cerebral blood volume; no decelerations were seen in either fetus. Mean cerebral hemoglobin oxygen saturation calculated during normal contractions was 43% ± 10% (SD).
      Conclusion: Uterine contractions were associated with detectable changes from baseline in cerebral oxyhemoglobin, deoxyhemoglobin, and cerebral blood volume.

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