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The California Maternal Serum α-Fetoprotein Screening Program: The role of ultrasonography in the detection of spina bifida

  • Author Footnotes
    a From the Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine
    Lawrence D. Platt
    Correspondence
    Reprint requests: Lawrence D. Platt, MD, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center/UCLA, 8700 Beverly Blvd., Los Angeles, CA 90048-1869.
    Footnotes
    a From the Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine
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  • Author Footnotes
    b From the Genetic Disease Branch, California Department of Health Services
    Lisa Feuchtbaum
    Footnotes
    b From the Genetic Disease Branch, California Department of Health Services
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  • Author Footnotes
    c From the Department of Radiology, University of California San Francisco School of Medicine.
    Roy Filly
    Footnotes
    c From the Department of Radiology, University of California San Francisco School of Medicine.
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  • Author Footnotes
    b From the Genetic Disease Branch, California Department of Health Services
    Linda Lustig
    Footnotes
    b From the Genetic Disease Branch, California Department of Health Services
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  • Author Footnotes
    b From the Genetic Disease Branch, California Department of Health Services
    Michele Simon
    Footnotes
    b From the Genetic Disease Branch, California Department of Health Services
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  • Author Footnotes
    b From the Genetic Disease Branch, California Department of Health Services
    George C. Cunningham
    Footnotes
    b From the Genetic Disease Branch, California Department of Health Services
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  • Author Footnotes
    a From the Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine
    b From the Genetic Disease Branch, California Department of Health Services
    c From the Department of Radiology, University of California San Francisco School of Medicine.
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      Between January 1988 and June 1990, 161 cases of open spina bifida were identified by the California Maternal Serum α-Fetoprotein Screening Program. Eight percent of these cases were not diagnosed by an initial ultrasonographic evaluation. Three defects were not recognized until birth. Ultrasonography is inadequate to identify all cases of open spina bifida.

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