Etiology and epidemiology of endometriosis

  • Robert L. Barbieri
    Reprint requests: Robert L. Barbieri, MD, Department of Obstetrics and Gynecology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115.
    Department of Obstetrics and Gynecology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts
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      The true prevalence of endometriosis remains undetermined because diagnostic laparoscopy cannot be performed on large, random, population-based samples of women. However, available evidence suggests that the disease occurs in approximately 1% to 7% of women in the United States. The cause of endometriosis is thought to be associated with mechanical factors (such as retrograde menstrual flow) or estrogen production. Recent research also has suggested that regular exercise may help to protect against the disease by decreasing the rate of estrogen production.

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      1. McCarthy E. Inpatient utilization of short-stay hospitals by diagnosis: United States, 1980. Vital and Health Statistics, series 13: data from National Health Survey No. 74. DHHS publication No. PHS 83-7735. Hyattsville, MD: National Center for Health Statistics, 1982.

        • Cramer DW
        Epidemiology of endometriosis.
        in: Wilson EA Endometriosis. Alan R. Liss, New York1987: 5-22
        • Wheeler JM
        • Malinak LR
        How common is endometriosis? Proper prevalence estimates demand uniform case definition and cohort assembly from a large population, Presented at the Forty-fourth Meeting of the American Fertility Society. Atlanta, Ga.1988
        • Boling RO
        • Abbasi R
        • Ackerman G
        • et al.
        Disability from endometriosis in the United States Army.
        J Reprod Med. 1988; 33: 49-52
        • Cramer DW
        • Wilson E
        • Stillman RJ
        • et al.
        The relation of endometriosis to menstrual characteristics, smoking and exercise.
        JAMA. 1985; 255: 1904-1908
        • Olive DL
        • Henderson DY
        Endometriosis and mullerian anomalies.
        Obstet Gynecol. 1987; 69: 412-415
        • Pinsonneault O
        • Goldstein DP
        Obstructing malformations of the uterus and vagina.
        Fertil Steril. 1985; 44: 241-247
        • Melicow MM
        • Pachter MR
        Endometrial carcinoma of the prostatic utricle (uterus masculinus).
        Cancer. 1967; 20: 1715
        • Olikar AF
        • Harns AE
        Endometriosis of the bladder in a male patient.
        J Urol. 1971; 106: 858
        • Pinkert TC
        • Catlow CE
        • Straus R
        Endometriosis of the urinary bladder in a man with prostatic carcinoma.
        Cancer. 1979; 43: 1562
        • Schrodt GR
        • Alcorn MD
        • Ibanez J
        Endometriosis of the male urinary system: a case report.
        J Urol. 1980; 124: 722
        • Snow R
        • Barbieri RL
        • Frisch RA
        Estrogen 2-hydroxylase activity and menstrual function in elite oarswomen.
        J Clin Endocrinol Metab. 1989; 69: 369-376