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Lipid peroxidation in pregnancy: New perspectives on preeclampsia

  • Carl A. Hubel
    Correspondence
    Reprint requests: Carl A. Hubel, PhD, Department of Obstetrics and Gynecology, The University of Vermont College of Medicine, Given Building, Burlington, VT 05405.
    Affiliations
    From the Department of Obstetrics and Gynecology, Burlington, University of Vermont College of Medicine, Vermont and the Departments of Medicine, Laboratory Medicine, and Obstetrics, Gynecology and Reproductive Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California
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  • James M. Roberts
    Affiliations
    From the Department of Obstetrics and Gynecology, Burlington, University of Vermont College of Medicine, Vermont and the Departments of Medicine, Laboratory Medicine, and Obstetrics, Gynecology and Reproductive Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California
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  • Robert N. Taylor
    Affiliations
    From the Department of Obstetrics and Gynecology, Burlington, University of Vermont College of Medicine, Vermont and the Departments of Medicine, Laboratory Medicine, and Obstetrics, Gynecology and Reproductive Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California
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  • Thomas J. Musci
    Affiliations
    From the Department of Obstetrics and Gynecology, Burlington, University of Vermont College of Medicine, Vermont and the Departments of Medicine, Laboratory Medicine, and Obstetrics, Gynecology and Reproductive Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California
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  • George M. Rogers
    Affiliations
    From the Department of Obstetrics and Gynecology, Burlington, University of Vermont College of Medicine, Vermont and the Departments of Medicine, Laboratory Medicine, and Obstetrics, Gynecology and Reproductive Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California
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  • Margaret K. McLaughlin
    Affiliations
    From the Department of Obstetrics and Gynecology, Burlington, University of Vermont College of Medicine, Vermont and the Departments of Medicine, Laboratory Medicine, and Obstetrics, Gynecology and Reproductive Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California
    Search for articles by this author
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      Abstract

      Basic research during the past two decades has led to increased awareness of the role of lipid peroxidation in various physiologic and pathophysiologic processes. A number of reports indicate that preeclampsia is associated with elevated blood levels of lipid peroxidation products. In view of its potentially destructive character, uncontrolled lipid peroxidation has been suggested as an etiologic factor in preeclampsia. The present article summarizes current information regarding the occurrence of lipid peroxidation in normal and preeclamptic pregnancy. Recent progress concerning our understanding of the process of lipid peroxidation and its role in cardiovascular disease is also reviewed. This information is used to discuss potential mechanisms by which lipid peroxidation might contribute to the pathogenesis of preeclampsia.

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