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Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions

  • C.M. Fredericks
    Correspondence
    Reprint requests: Dr. C. M. Fredericks, Department of Physiology, Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29425.
    Affiliations
    Department of Physiology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Al-Azhar Faculty of Medicine Cairo, Egypt.
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  • I. Kotry
    Affiliations
    Department of Physiology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Al-Azhar Faculty of Medicine Cairo, Egypt.
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  • G. Holtz
    Affiliations
    Department of Physiology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Al-Azhar Faculty of Medicine Cairo, Egypt.
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  • A.H. Askalani
    Affiliations
    Department of Physiology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Al-Azhar Faculty of Medicine Cairo, Egypt.
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  • G.I. Serour
    Affiliations
    Department of Physiology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Medical University of South Carolina Charleston, South Carolina USA

    Department of Obstetrics and Gynecology, Al-Azhar Faculty of Medicine Cairo, Egypt.
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      Abstract

      With the use of a rabbit surgical model, the ability of 1%, 2%, and 3% solutions of sodium carboxymethylcellulose to reduce postoperative uterine adhesions was determined. At all concentrations sodium carboxymethylcellulose was more effective than either 32% dextran 70 or heparinized lactated Ringer's solution. Neither the dextran nor Ringer's solution had a significant (p ≤ 0.05) effect. The beneficial effects of sodium carboxymethylcellulose were closely dose-dependent (correlation coefficient 0.97). Sodium carboxymethylcellulose is highly effective in reducing postoperative adhesions in laboratory animals, and additional studies are warranted to further define its efficacy and safety.

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      References

        • Ellis H
        The aetiology of post-operative abdominal adhesions: an experimental study.
        Br J Surg. 1962; 50: 10
        • Fedor R
        • Miko I
        • Nagy Jr, T
        The role of ischaemia in the formation of postoperative intraabdominal adhesions.
        Acta Chir Hung. 1983; 24: 3
        • Raftery AT
        Effect of peritoneal trauma on peritoneal fibrinolytic activity and intraperitoneal adhesion formation—an experimental study in the rabbit.
        Eur Surg Res. 1981; 13: 397
        • Nisell H
        • Larsson B
        Role of blood and fibrinogen in development of intraperitoneal adhesions in rats.
        Fertil Steril. 1978; 30: 470
        • Delbeke LO
        • Gomez V
        • McComb PF
        • Jetha N
        Histologic reaction to four synthetic microsutures in the rabbit.
        Fertil Steril. 1983; 40: 248
        • Henderson WJ
        • Melville-Johnes C
        • Barr WT
        • Griffiths K
        Identification of talc on surgeons gloves and in tissues from starch granulomas.
        Br J Surg. 1975; 62: 941
        • diZerega GS
        • Holtz G
        The cause and prevention of post-surgical adhesions.
        in: Advances in obstetrics and gynecology. Williams & Wilkins, Baltimore1982: 277
        • Holtz G
        Prevention and management of peritoneal adhesions.
        Fertil Steril. 1984; 41: 497
        • Luciano AA
        • Hauser KS
        • Bender J
        Evaluation of commonly used adjuvants in the prevention of postoperative adhesions.
        Am J Obstet Gynecol. 1983; 146: 88
        • Elkins TE
        • Bury RJ
        • Ritter JL
        • et al.
        Adhesion prevention by solutions of sodium carboxymethylcellulose in the rat. I.
        Fertil Steril. 1984; 41: 926
        • Elkins TE
        • Ling FW
        • Ahokas RA
        • Abdella TN
        • Homsey CA
        • Malinak LR
        Adhesion prevention by solutions of sodium carboxymethylcellulose in the rat. II.
        Fertil Steril. 1984; 41: 929
        • Homsy CA
        • Stanley RF
        • King JW
        Pseudosynovial fluids based on sodium carboxymethylcellulose.
        in: Gabelnick HL Litt M Rheology of biological systems. Charles C Thomas, Springfield, Illinois1973: 278
        • Holtz G
        Current use of ancillary modalities for adhesion prevention.
        Fertil Steril. 1985; 44: 174
        • Rosenberg SM
        • Board JA
        High-molecular weight dextran in human infertility surgery.
        Am J Obstet Gynecol. 1984; 148: 380
        • Borten M
        • Seibert CP
        • Taymor ML
        Recurrent anaphylactic reaction to intraperitoneal dextran 75 used for prevention of postsurgical adhesion.
        Obstet Gynecol. 1983; 61: 755
        • Elkins TE
        • Trenthem L
        • McNeely Jr, SG
        • et al.
        Potential for in vitro growth of common bacteria in solutions of 32% dextran 70 and 1.0% sodium carboxymethylcellulose.
        Fertil Steril. 1985; 43: 477