Intrauterine intravascular transfusions for severe red blood cell isoimmunization: Ultrasound-guided percutaneous approach

      This paper is only available as a PDF. To read, Please Download here.


      Eight pregnancies with severe red blood cell isoimmunization were managed with use of an intravascular approach for intrauterine transfusions. Fetoscopy was not employed, and the procedures were performed percutaneously under direct ultrasound visualization. A total of 16 of 18 attempted transfusions were successfully performed, with four fetuses requiring more than one transfusion. Technical aspects of the procedure as well as its indications, advantages, and drawbacks are discussed.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to American Journal of Obstetrics & Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Rodeck CH
        • Holman CA
        • Karnicki J
        • Kemp JR
        • Whitmore DN
        • Austin MA
        Direct intravascular fetal blood transfusion by fetoscopy in severe Rhesus isoimmunisation.
        Lancet. 1981; 1: 625
        • Ch de Crespigny L
        • Robinson HP
        • Quinn M
        • Doyle L
        • Ross A
        • Cauchi M
        Ultrasound-guided fetal blood transfusion for severe Rhesus isoimmunization.
        Obstet Gynecol. 1985; 66: 529
        • Berkowitz RL
        • Chitkara U
        • Goldberg JD
        • Wilkins I
        • Chervenak FA
        Intrauterine transfusion in utero: the percutancous approach.
        Am J Obstet Gynecol. 1986; 154: 622
        • Jeanty P
        • Rodesch F
        • Romero R
        • Venus I
        • Hobbins JC
        How to improve your amniocentesis technique.
        Am J Obstet Gynecol. 1983; 146: 593
        • MacKenzie IZ
        • MacLean DA
        • Fry A
        • Evans SL
        Midtrimester intrauterine exchange transfusion of the fetus.
        Am J Obstet Gynecol. 1982; 143: 555
        • Rodeck CH
        • Nicolaides KH
        • Warsof LS
        • Fysh WJ
        • Gamsu HR
        • Kemp JR
        The management of severe rhesus iso-immunization by fetoscopic intravascular transfusions.
        Am J Obstet Gynecol. 1984; 150: 769
        • Bang J
        • Bock JE
        • Trolle D
        Ultrasound-guided fetal intravenous transfusion for severe rhesus haemolytic disease.
        Br Med J. 1982; 284: 373
        • Daffos F
        • Capella-Pavlosky M
        • Forestier F
        Fetal blood sampling via the umbilical cord using a needle guided by ultrasound.
        Prenat Diagn. 1983; 3: 271
        • Daffos F
        • Forestier F
        • Muller JY
        • et al.
        Prenatal treatment of alloimmune thrombocytopenia.
        Lancet. 1984; 2: 632
        • Liley AW
        Intrauterine transfusion of foetus in haemolytic disease.
        Br Med J. 1963; 2: 1107
        • Berkowitz RL
        Intrauterine transfusion, 1980: An update.
        Clin Perinatol. 1980; 7: 285
        • Bowman JM
        • Manning FA
        Intrauterine fetal transfusions: Winnipeg 1982.
        Obstet Gynecol. 1983; 61: 203
        • Daffos F
        • Forestier F
        • Capella-Pavlosky M
        Fetal Blood sampling during the third trimester of pregnancy.
        Br J Obstet Gynaecol. 1984; 91: 118
        • Daffos F
        • Capella-Pavlovsky M
        • Forestier F
        Fetal blood sampling during pregnancy with use of a needle guided by ultrasound: a study of 606 consecutive cases.
        Am J Obstet Gynecol. 1985; 153: 655