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Intravenous versus intraperitoneal administration of dextran in the rabbit: Effects on fibrinolysis

  • Rebecca Wagaman
    Correspondence
    Reprint requests: Rebecca Wagaman, M.D., Department of Obstetrics and Gynecology, University of Florida, College of Medicine, Box J-294, JHMHC, Gainesville, FL 32610.
    Footnotes
    Affiliations
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine Tampa, Florida USA

    the Division of Hematology, Department of Internal Medicine, University of South Florida College of Medicine Tampa, Florida USA

    James A. Haley Veterans Hospital Tampa, Florida USA
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  • James M. Ingram
    Affiliations
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine Tampa, Florida USA

    the Division of Hematology, Department of Internal Medicine, University of South Florida College of Medicine Tampa, Florida USA

    James A. Haley Veterans Hospital Tampa, Florida USA
    Search for articles by this author
  • Papineni S. Rao
    Affiliations
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine Tampa, Florida USA

    the Division of Hematology, Department of Internal Medicine, University of South Florida College of Medicine Tampa, Florida USA

    James A. Haley Veterans Hospital Tampa, Florida USA
    Search for articles by this author
  • Hussain I. Saba
    Affiliations
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine Tampa, Florida USA

    the Division of Hematology, Department of Internal Medicine, University of South Florida College of Medicine Tampa, Florida USA

    James A. Haley Veterans Hospital Tampa, Florida USA
    Search for articles by this author
  • Author Footnotes
    ∗ Supported by The South Atlantic Association of Obstetricians and Gynecologists Student Fellowship.
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      Abstract

      Adhesions are the leading cause of small bowel obstruction and a frequent cause of failure of infertility operations. Fibrinolysis is involved in the formation and resolution of adhesions. Although intravenous dextran (Macrodex) is known to augment intravascular fibrinolysis, the effects of intraperitoneal dextran (Hyskon) on fibrinolysis have not been extensively studied. A fibrin plate assay system was used to assess plasminogen activator activity of rabbit peritoneum and plasma after treatment with intraperitoneal or intravenous dextran 70. Hyskon significantly reduced the ability of severe trauma to depress plasminogen activator activity of visceral peritoneum and was capable of direct plasminogen activation. Untraumatized or minimally traumatized peritoneum was not affected, nor was plasminogen activator activity of plasma. Pulmonary effusions and perioperative deaths were significantly associated with the use of Hyskon.

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