Is prostaglandin E2 really of therapeutic value for postoperative urinary retention? Results of a prospectively randomized double-blind study

      This paper is only available as a PDF. To read, Please Download here.


      In a prospectively randomized double-blind study 28 patients with urinary retention after anterior colporrhaphy were administered either placebo or prostaglandin E2 in different doses (0.75 mg, 1.5 mg, or 2.25 mg) intravesically on postoperative days 6 and 7. Urodynamic assessment was performed before and after treatment. A moderate but not significant decrease of maximum bladder capacity, bladder compliance, and maximum urethral closure pressure was found in patients treated with 2.25 mg of prostaglandin E2. These urodynamic changes did not correspond to the clinical outcome: Residual urine decreased and effective bladder capacity increased significantly in all four groups uninfluenced by the type of therapy. The rate of success (defined by the amounts of residual urine after therapy) was similar in the four groups. A long-term effect of prostaglandin E2 could also be excluded, since the mean time interval from operation to the first day without residual urine was similar in the four groups. Therefore the therapeutic value of intravesically administered prostaglandin E2 in doses from 0.75 to 2.25 mg must be seriously questioned.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to American Journal of Obstetrics & Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Crisp WE
        • Sattenspiel E
        The morbidity of hysterectomy.
        Surg Gynecol Obstet. 1965; 121: 965-971
        • Stanton SL
        • Cardozo L
        • Chaudhury H
        Spontaneous voiding after surgery for urinary incontinence.
        Br J Obstet Gynecol. 1978; 85: 149-152
        • Hirsch HA
        Postoperative Komplikationen nach vaginaler Hysterektomie und Inkontinenzoperationen.
        Gynäk Rdsch. 1979; 19: 76-91
        • Wein AJ
        Pharmacology of the bladder and urethra.
        in: Stanton SL Tanagho EA Surgery of female incontinence. Springer-Verlag, New York1980
        • Andersson K-E
        • Henriksson L
        • Ulmsten U
        Effects of prostaglandin E2 applied locally on intravesical and intraurethral pressures in women.
        Eur Urol. 1978; 4: 366-369
        • Desmond AD
        • Bultitude MI
        • Hills NH
        • Shuttleworth KED
        Clinical experience with intravesical prostaglandin E2.
        Br J Urol. 1980; 52: 357-366
        • Grünberger W
        • Tulzer H
        Zur Therapie der postoperativen Harnverhaltung mit Prostaglandin.
        Geburtshilfe Frauenheilkd. 1981; 41: 20-22
        • Riss P
        • Spernol R
        • Gruber W
        Intravesikales Prostaglandin E2 und Plazebo bei Harnverhaltung nach gynäkologischen.
        Operationen. Geburtshilfe Frauenheilkd. 1982; 42: 182-184
        • Eberhard J
        • Lienhard P
        Die Streßinkontinenz der Frau. Auswertung und Interpretation der Urethradruckprofile.
        Geburtshilfe Frauenheilkd. 1979; 39: 195-208
        • Madersbacher H
        • Märk R
        • Janetschek G
        Technik und Interpretation der Zystometrie.
        Therapiewoche. 1979; 29: 43-52
        • Melchior H
        Urologische Funktionsdiagnostik.
        in: ]Lehrbuch und Atlas der Urodynamik. Thieme Verlag, Stuttgart1981
        • Hills NH
        Prostaglandins and tone in isolated strips of mammalian bladder.
        Br J Pharmacol. 1976; 57: 464-465
        • Khanna OP
        • Barbieri EJ
        • McMichael R
        Effects of prostaglandins on vesico-urethral smooth muscle of rabbit.
        Urology. 1978; 12: 674-681
        • Abrams PH
        • Feneley RCL
        The action of prostaglandins on the smooth muscle of the human urinary tract in vitro.
        Br J Urol. 1967; 47: 909-912
        • Andersson KE
        • Ek A
        • Persson CGA
        Effects of prostaglandins on the isolated human bladder and urethra.
        Acta Physiol Scand. 1977; 100: 165-171
        • Bultitude MJ
        • Hills NA
        • Shuttleworth KED
        Clinical and experimental studies on the action of prostaglandins and their synthesis inhibitors on detrusor muscle in vitro and in vivo.
        Br J Urol. 1976; 48: 631-637
        • Ratnam SS
        • Prasad RNV
        • Karim SMM
        Management of postsurgical urinary retention with prostaglandin F2—a preliminary report.
        Singapore J Obstet Gynecol. 1979; 10: 23-26
        • Delaere KPJ
        • Thomas CMG
        • Moonen WA
        • Debruyne FMJ
        The value of intravesical prostaglandin E2 and F in women with abnormalities of bladder emptying.
        Br J Urol. 1981; 53: 306-309
        • Köller A
        • Nürnberger N
        • Pflüger H
        Prostaglandin E2—Eine Bereicherung in der Therapie der Blasenentle-erungsstörungen.
        Z Urol u Nephrol. 1983; 76: 145-149