Pulsatile administration of gonadotropin-releasing hormone for induction of ovulation

A. Loucopoulos; M. Ferin; R.L. Vande Wiele; I. Dyrenfurth; D. Linkie; M. Yeh; R. Jewelewicz

doi:10.5555/uri:pii:0002937884905313

Transactions of the Second Annual Meeting of the American Gynecological and Obstetrical Society| Volume 148, ISSUE 7, P895-900, April 01, 1984

Pulsatile administration of gonadotropin-releasing hormone for induction of ovulation

A. Loucopoulos
A. Loucopoulos
Affiliations
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons New York, New York USA.
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M. Ferin
M. Ferin
Affiliations
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons New York, New York USA.
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R.L. Vande Wiele
R.L. Vande Wiele
Affiliations
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons New York, New York USA.
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I. Dyrenfurth
I. Dyrenfurth
Affiliations
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons New York, New York USA.
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D. Linkie
D. Linkie
Affiliations
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons New York, New York USA.
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M. Yeh
M. Yeh
Affiliations
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons New York, New York USA.
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R. Jewelewicz
R. Jewelewicz
Correspondence
Reprint requests: Dr. Raphael Jewelewicz, Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons, 630 West 168th St., New York, New York 10032.
Affiliations
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons New York, New York USA.
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DOI:https://doi.org/10.5555/uri:pii:0002937884905313

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Abstract

Chronic pulsatile administration of gonadotropin-releasing hormone (GnRH) was used to induce ovulation in 12 women with various ovulatory disorders. In the first group of eight patients with normal to low baseline levels of gonadotropin, seven responded favorably to the treatment. Follicular maturation was observed in 57% of the treated cycles, and normal ovulatory cycles were induced in 24% of the patients. Two patients became pregnant. The intravenous route of administration was more effective than the subcutaneous one, possibly in response to the GnRH profile after each pulse. (The amplitude of GnRH peaks after an intravenous pulse was four times that seen after a subcutaneous one.) In contrast, follicular maturation and ovulation could not be induced in four women of a second group of patients with normal baseline levels of follicle-stimulating hormone but with high and frequent pulses of luteinizing hormone. The conclusion reached was that pulsatile administration of GnRH can be a new therapeutic tool in the treatment of ovulatory disorders in women who have an insufficient endogenous release of GnRH.

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Footnotes

☆Supported by Grant RR00645 from the National Institutes of Health.

☆☆Presented by invitation at the Second Annual Meeting of the American Gynecological and Obstetrical Society, Phoenix, Arizona, September 7–10, 1983.

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DOI: https://doi.org/10.5555/uri:pii:0002937884905313

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Pulsatile administration of gonadotropin-releasing hormone for induction of ovulation

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