This paper is only available as a PDF. To read, Please Download here.
Abstract
Concentrations of ibuprofen in breast milk and serum were compared in 12 patients
who had ingested one 400 mg tablet of ibuprofen every 6 hours over a 24-hour period
for relief of post-cesarean section pain. Samples of breast milk and blood were obtained
simultaneously over a 34-hour period beginning just prior to the first dose of ibuprofen.
Gas-liquid chromatography assay methodology capable of detecting 1 μg/ml was used
to determine concentrations of ibuprofen in serum and breast milk. Ibuprofen was present
in the serum with a half-life of approximately 1.5 hours. No measurable amounts of
ibuprofen were found in the samples of breast milk. The conclusion drawn is that,
in lactating women who take up to 400 mg of ibuprofen every 6 hours, less than 1 mg
of ibuprofen per day is excreted in breast milk.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of Obstetrics & GynecologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Milk and lactation: Some social and developmental correlates among 1,000 infants.Pediatrics. 1982; 69: 169
- Prevalence and advantages of breast feeding.in: Wilson J.T. Drugs in Breast Milk. A D I S Press, Balgowlah, Australia1981: 2-3
- Policy statement based on task force report: The promotion of breast-feeding.Pediatrics. 1982; 69: 654
- Prescribing for the breast-feeding patient.Practitioner. 1981; 225: 920
- Commentary: When should one discourage breast-feeding.Pediatrics. 1981; 67: 300
- Drugs and breast feeding.Drug Intell. Clin. Pharm. 1977; 11: 208
- Drugs and breast milk.Pediatr. Clin. North Am. 1972; 19: 151
- Drugs and the nursing mother-infant.U. S. Pharmacist. 1978; 3: 39
- Breast milk: A source of more than nutrition for the neonate.Clin. Toxicol. 1974; 7: 69
- Excretion of drugs in human breast milk.Drug Metab. Rev. 1981; 12: 261
- Increasing prevalence of breast-feeding.Br. Med. J. 1978; 2: 1122
- The recent trend in breast-feeding.Pediatrics. 1981; 67: 260
- Motrin tablets package insert.September, 1982
- Lack of ibuprofen secretion into human milk.Clin. Pharm. 1983; 1: 457
- Gas-liquid chromatography determination of ibuprofen in plasma.J. Pharm. Sci. 1974; 63: 219
- Drugs and breast milk feeding.Semin. Perinatol. 1979; 3: 271
- Production and characteristics of breast milk.in: Wilson J.T. Drugs in Breast Milk. A D I S Press, Balgowlah, Australia1981: 4-14
Article info
Publication history
Accepted:
November 15,
1983
Received in revised form:
October 21,
1983
Received:
August 1,
1983
Identification
Copyright
© 1984 Published by Elsevier Inc.
