Advertisement

Leiomyosarcoma of the uterus

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      A series of 43 cases of uterine leiomyosarcoma was reviewed. Forty-one of the 43 patients were followed up 2 or more years. The overall 5-year survival was 73%. Favorable prognostic features included the premenopausal status of the patient, the confinement of the tumor within a myoma, the low mitotic count (less than four mitotic figures in any one high-power field or less than four mitotic figures per 10 high-power fields), the absence of necrosis, and the presence of hyalinization in the adjacent tissue suggesting confinement. Special cases such as those in which only myomectomy was performed and those receiving adjunctive chemotherapy are discussed. The differential in survival between patients with primary myosarcoma and those with lesions arising in a leiomyoma is stressed.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Obstetrics & Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Christopherson W.M.
        • Williamson E.O.
        • Gray L.A.
        Leiomyosarcoma of the uterus.
        Cancer. 1972; 29: 1512
        • Montague A.C.W.
        • Swartz D.P.
        • Woodruff J.D.
        Sarcoma arising in a leiomyoma of the uterus.
        Am. J. Obstet. Gynecol. 1965; 92: 421
        • Hart W.R.
        • Billman J.K.
        A reassessment of uterine neoplasms originally diagnosed as leiomyosarcomas.
        Cancer. 1978; 41: 1902
        • Kurman R.J.
        • Norris H.J.
        Mesenchymal tumors of the uterus. VI. Epithelioid smooth muscle tumors including leiomyoblastoma and clear cell leiomyoma. A clinical and pathological study.
        Cancer. 1976; 37: 1853
        • Gallup D.G.
        • Cordray D.R.
        Leiomyosarcoma of the uterus: Case reports and a review.
        Obstet. Gynecol. Surv. 1979; 34: 300
        • Vardi J.R.
        • Tovell H.M.M.
        Leiomyosarcoma of the uterus: Clinicopathologic study.
        Obstet. Gynecol. 1980; 56: 428
        • Silverberg S.G.
        Leiomyosarcoma of the uterus. A clinicopathologic study.
        Obstet. Gynecol. 1971; 38: 613
        • Hannigan E.V.
        • Gomez L.G.
        Uterine leiomyosarcoma. A review of prognostic and pathologic features.
        Am. J. Obstet. Gynecol. 1979; 134: 557
        • Azizi F.
        • Bitran J.
        • Jahevari G.
        • Herbst A.L.
        Remission of uterine leiomyosarcomas treated with vincristine, Adriamycin, and dimethyl-triazeno-imidazole carboximide.
        Am. J. Obstet. Gynecol. 1979; 133: 379
        • Hendrikson M.R.
        • Kempson R.L.
        Smooth muscle neoplasms.
        in: Surgical Pathology of the Uterus. W. B. Saunders Company, Philadelphia1980: 468-529
        • Taylor H.B.
        • Norris H.J.
        Mesenchymal tumors of the uterus. IV. Diagnosis and prognosis of leiomyosarcomas.
        Arch. Pathol. 1966; 82: 40
        • Silverberg S.G.
        Reproducibility of the mitosis count in the histologic diagnosis of smooth muscle tumors of the uterus.
        Hum. Pathol. 1976; 7: 451