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Reduced umbilical artery prostacyclin formation in complicated pregnancies

  • Christian Dadak
    Correspondence
    Reprint requests: Christian Dadak, M.D., Second Department of Gynecology and Obstetrics, University of Vienna, Spitalgasse 23, A-1090 Vienna, Austria
    Affiliations
    Second Department of Gynecology and Obstetrics, Atherosclerosis Research Group Vienna, Austria

    Department of Medical Physiology, University of Vienna; Vienna, Austria

    the Atherosclerosis Research Center, University of Siena, Siena, Italy
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  • Achilleus Kefalides
    Footnotes
    Affiliations
    Second Department of Gynecology and Obstetrics, Atherosclerosis Research Group Vienna, Austria

    Department of Medical Physiology, University of Vienna; Vienna, Austria

    the Atherosclerosis Research Center, University of Siena, Siena, Italy
    Search for articles by this author
  • Helmut Sinzinger
    Affiliations
    Second Department of Gynecology and Obstetrics, Atherosclerosis Research Group Vienna, Austria

    Department of Medical Physiology, University of Vienna; Vienna, Austria

    the Atherosclerosis Research Center, University of Siena, Siena, Italy
    Search for articles by this author
  • Giorgio Weber
    Affiliations
    Second Department of Gynecology and Obstetrics, Atherosclerosis Research Group Vienna, Austria

    Department of Medical Physiology, University of Vienna; Vienna, Austria

    the Atherosclerosis Research Center, University of Siena, Siena, Italy
    Search for articles by this author
  • Author Footnotes
    ∗ Research Fellow supported by a grant from the Atherosclerosis Research Group, Vienna.
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      Abstract

      Prostacyclin synthesis is severely depressed in the umbilical arteries of neonates of mothers with gestational diabetes mellitus, juvenile-onset diabetes mellitus, or preeclamptic symptoms, and of mothers who smoke during pregnancy and diabetic mothers who smoke. The reduced production of prostacyclin might be responsible for an increased abortion rate and a higher rate of intrauterine fetal death because of a decrease in placental perfusion and umbilical blood flow.
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