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Abstract
A prospective study was undertaken to evaluate the use of glycohemoglobin (HbA1) as a screening tool for the detection of gestational diabetes in 90 subjects. At
28 to 30 weeks, these patients had an HbA1 determination prior to diabetes screening with a 1-hour serum glucose after 50 gm
of oral glucose. Those women with an abnormal screening result were then evaluated
with a standard 3-hour oral glucose tolerance test. Forty-seven women had an abnormal
1-hour serum glucose (≥ 140 mg/dl). Nine of these 47 women (19%) had an abnormal HbA1. Four of these nine women (44.4%) with an abnormal screening glucose as well as an
abnormal HbA1 demonstrated an abnormal oral glucose tolerance test. Eleven of 38 women (29%) with
an abnormal glucose screen but normal HbA1 had an abnormal glucose tolerance test. The combination of two abnormal tests, glucose
screen and HbA1, predicted gestational diabetes in only four of 15 (27%) of our patients. The sensitivity
and specificity of this combination were 22.4% and 87.8%, respectively. The median
values of HbA1 with normal and abnormal glucose tolerance tests were 7.8% (range, 4.9% to 11.5%)
and 8.2% (range, 5.4% to 12%), respectively. These values were not significantly different.
These data confirm that HbA1 alone or in combination with a 50 gm glucose screen is not a sensitive screening
tool for the detection of gestational diabetes mellitus.
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Article Info
Publication History
Accepted:
July 13,
1982
Received in revised form:
June 16,
1982
Received:
March 16,
1982
Identification
Copyright
© 1982 Published by Elsevier Inc.
