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Uterine and peripheral blood concentrations of vasodilator prostaglandins in conscious pregnant rabbits

  • G. Chaudhuri
    Affiliations
    Department of Medicine, State University of New York at Buffalo, School of Medicine Buffalo, New York USA

    Department of Obstetrics and Gynecology, State University of New York at Buffalo, School of Medicine Buffalo, New York USA
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  • P. Barone
    Affiliations
    Department of Medicine, State University of New York at Buffalo, School of Medicine Buffalo, New York USA

    Department of Obstetrics and Gynecology, State University of New York at Buffalo, School of Medicine Buffalo, New York USA
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  • E. Lianos
    Affiliations
    Department of Medicine, State University of New York at Buffalo, School of Medicine Buffalo, New York USA

    Department of Obstetrics and Gynecology, State University of New York at Buffalo, School of Medicine Buffalo, New York USA
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  • M. Hurd
    Affiliations
    Department of Medicine, State University of New York at Buffalo, School of Medicine Buffalo, New York USA

    Department of Obstetrics and Gynecology, State University of New York at Buffalo, School of Medicine Buffalo, New York USA
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  • A. Lele
    Affiliations
    Department of Medicine, State University of New York at Buffalo, School of Medicine Buffalo, New York USA

    Department of Obstetrics and Gynecology, State University of New York at Buffalo, School of Medicine Buffalo, New York USA
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  • R. Venuto
    Correspondence
    Reprint requests: Rocco C. Venuto, M.D., Renal Division—Room 503, Erie County Medical Center, 462 Grider St., Buffalo, New York 14215
    Affiliations
    Department of Medicine, State University of New York at Buffalo, School of Medicine Buffalo, New York USA

    Department of Obstetrics and Gynecology, State University of New York at Buffalo, School of Medicine Buffalo, New York USA
    Search for articles by this author
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      Abstract

      The concentrations of prostaglandin E2 (PGE2) and prostacyclin (PGI2) were estimated in blood obtained from the uterine venous effluent and a peripheral artery of conscious pregnant and nonpregnant rabbits. The blood was analyzed both with a superfusion bioassay and radioimmunoassays. PGE2, but not PGI2, was detected in a very high concentration in the uterine venous effluent of the pregnant rabbit. The peripheral blood of pregnant animals also revealed increased levels of only PGE2. The results of both assay techniques correlated closely. These studies suggest that the uteroplacental unit is the source of the increased peripheral level of the potent vasodilator PGE2. In contrast, these data fail to support the notion that PGI2 is the primary systemic-acting vasodepressor prostaglandin in rabbit pregnancy.
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