A simplified technique to produce toxemia in the pregnant dog

  • M.Maurice Abitbol
    Reprint requests: M. Maurice Abitbol, M.D., Chairman, Department of Obstetrics and Gynecology, The Jamaica Hospital, 89th Ave. and Van Wyck Expressway, Jamaica, New York, 11418
    Department of Obstetrics and Gynecology, The Jamaica Hospital, Jamaica, New York, USA
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      In 39 pregnant and six nonpregnant dogs the abdominal aorta was exposed extraperitoneally through a left paralumbar incision, and a vascular occluder and a flow transducer were placed around it. The tubing of the occluder and the wiring of the flow transducer were slipped under the skin and advanced to the back of the neck of the animal. Thus, the aortic blood flow could be progressively reduced and continuously monitored. After 4 to 20 days of blood flow reduction of 35% to 75%, the picture of a moderately severe toxemia appeared in 10 dogs and that of a mild toxemia was seen in the 11 others. Nine animals were eliminated because of premature labor and three were eliminated for surgical complications. The control group (six pregnant animals with a sham operation and six nonpregnant animals with a severe aortic constriction) presented no abnormalities.
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        • Douglas B.H.
        ed. 6. Experimental Approaches to Toxemia of Pregnancy. Charles C Thomas, Publisher, Springfield, Illinois1971: 52
        • Ogden E.
        • Hildebrand G.J.
        • Page E.W.
        Rise of blood pressure during ischemia of the gravid uterus.
        in: ed. 6. Proc. Soc. Exp. Biol. Med. 43. 1940: 49
        • Douglas B.H.
        • Langford H.G.
        Postterm blood pressure elevation produced by uterine wrapping.
        Am. J. Obstet. Gynecol. 1967; 97: 231
        • Hodari A.A.
        Chronic uterine ischemia and reversible experimental toxemia of pregnancy.
        Am. J. Obstet. Gynecol. 1969; 97: 597
        • Cavanagh D.
        • Rao P.S.
        • Tung K.S.K.
        • Gaston L.
        Eclamptogenic toxemia: The development of an experimental model of the subhuman primate.
        Am. J. Obstet. Gynecol. 1974; 120: 183
        • Chesley L.C.
        • McFaul I.E.
        Studies on surviving human placental tissue.
        Am. J. Obstet. Gynecol. 1949; 58: 159
        • Beker J.C.
        Aetiology of eclampsia.
        J. Obstet. Gynaecol. Br. Emp. 1948; 55: 756
        • Abitbol M.M.
        • Gallo G.R.
        • Pirani C.L.
        • et al.
        Production of experimental toxemia in the pregnant rabbit.
        Am. J. Obstet. Gynecol. 1976; 124: 460
        • Abitbol M.M.
        • Pirani C.L.
        • Ober W.B.
        • et al.
        Production of experimental toxemia in the pregnant dog.
        Obstet. Gynecol. 1976; 48: 537
        • Abitbol M.M.
        • Ober W.B.
        • Gallo G.R.
        • et al.
        Experimental toxemia of pregnancy in the monkey: With a preliminary report on renin and aldosterone.
        Am. J. Pathol. 1977; 86: 573
        • Abitbol M.M.
        • Driscoll S.G.
        • Ober W.B.
        Placental lesions in experimental toxemia in the rabbit.
        Am. J. Obstet. Gynecol. 1976; 125: 942
        • Abitbol M.M.
        Intravascular coagulation in the experimental model of toxemia.
        N. Y. State J. Med. 1978; 78: 1397
        • Abitbol M.M.
        Hemodynamic studies in experimental toxemia of the dog.
        Obstet. Gynecol. 1977; 50: 293
        • Sheehan H.L.
        Pathological lesions in the hypertensive toxemias of pregnancy.
        in: Ciba Foundation Symposium. J. & A. Churchill, Ltd, London1950: 16-22
        • Sheehan H.L.
        • Lynch J.B.
        ed. 6. Pathology of Toxemia of Pregnancy. The Williams & Wilkins Co, Baltimore1973