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Possible relationship between in utero diethylstilbestrol exposure and male fertility

  • M.A. Stenchever
    Correspondence
    Reprint requests: Dr. M. A. Stenchever, Department of Obstetrics and Gynecology, RH-20, University of Washington School of Medicine, Seattle, Washington 98195
    Affiliations
    Department of Obstetrics and Gynecology University of Washington School of Medicine Seattle, Washington, USA.

    Department of Medicine, University of Washington School of Medicine Seattle, Washington, USA.
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  • R.A. Williamson
    Affiliations
    Department of Obstetrics and Gynecology University of Washington School of Medicine Seattle, Washington, USA.

    Department of Medicine, University of Washington School of Medicine Seattle, Washington, USA.
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  • J. Leonard
    Affiliations
    Department of Obstetrics and Gynecology University of Washington School of Medicine Seattle, Washington, USA.

    Department of Medicine, University of Washington School of Medicine Seattle, Washington, USA.
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  • L.E. Karp
    Affiliations
    Department of Obstetrics and Gynecology University of Washington School of Medicine Seattle, Washington, USA.

    Department of Medicine, University of Washington School of Medicine Seattle, Washington, USA.
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  • B. Ley
    Affiliations
    Department of Obstetrics and Gynecology University of Washington School of Medicine Seattle, Washington, USA.

    Department of Medicine, University of Washington School of Medicine Seattle, Washington, USA.
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  • K. Shy
    Affiliations
    Department of Obstetrics and Gynecology University of Washington School of Medicine Seattle, Washington, USA.

    Department of Medicine, University of Washington School of Medicine Seattle, Washington, USA.
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  • D. Smith
    Affiliations
    Department of Obstetrics and Gynecology University of Washington School of Medicine Seattle, Washington, USA.

    Department of Medicine, University of Washington School of Medicine Seattle, Washington, USA.
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      Abstract

      Seventeen men who were exposed in utero to diethylstillbestrol (DES), 12 non-DES-exposed volunteers, and 11 fertile control subjects were evaluated by physical examination, seminal fluid analysis, and sperm penetration assay (SPA). Fourteen of the 17 male subjects exposed to DES in utero and two of the 12 non-DES-exposed volunteers had SPAs of less than 14% and qualified as infertile by the criteria of this test. All 11 fertile control subjects had demonstrated SPA values in the fertile range. Thirteen of the 17 DES-exposed male subjects, four of the 12 non-DES-exposed volunteers, and four of the 11 fertile control subjects demonstrated at least one abnormality of the reproductive organs.
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