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Abstract
Systematic genetic studies in endometriosis apparently have not been conducted; therefore,
we studied 123 patients with histologically proved endometriosis. Nine of 153 (5.8%)
female sibs (over age 18) of patients with histologically proved endometriosis were
considered similarly affected; 10 of 123 mothers (8.1%) were affected; 19 of 276 (6.9%)
of all first-degree relatives were affected. By contrast, only one of 104 (1.0%) female
sibs of their husbands and only one of 107 (0.9%) mothers of their husbands were affected,
significantly (p < 0.05) less for both sibs and mothers. Several genetic etiologies
can be postulated, but polygenic/multifactorial inheritance seems most likely because
of (1) the 6.9% recurrence risk for all first-degree relatives and (2) observations
that the 18 patients with an affected first-degree relative were more likely to have
severe endometriosis than those without an affected first-degree relative.
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References
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Article Info
Footnotes
☆Presented at the Forty-seventh Annual Meeting of the Central Association of Obstetricians and Gynecologists, White Sulphur Springs, West Virginia, September 21–23, 1979.
Identification
Copyright
© 1980 Published by Elsevier Inc.
