Defects of the central nervous system in Finland

IV. Associations with diagnostic x-ray examinations
  • Gustav Granroth
    Reprint requests: Gustav Granroth, Department of Pathology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki 29,Finland.
    Department of Pathology, University of Helsinki, Helsinki, Finland
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      Based on the Finnish Register of Congenital Malformations a search was undertaken to find possible associations between defects of the CNS and diagnostic x-ray examinations of the mother during pregnancy as well as pelvic x-ray examinations prior to pregnancy. Time-area-matched pregnancies and polydactylic children were used as controls. The risk of having a microcephalic child was increased for mothers with pelvic x-ray prior to pregnancy, but the number of discordant pairs was small. Of the examinations performed during pregnancy, fetal x-ray was significantly more common among mothers who delivered a CNS-defective child. No associations were observed for other kinds of examinations.
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      2. Granroth, G., Haapakoski, J., and Hakama, M.: Defects of the central nervous system in Finland. II. Birth order, outcome of previous pregnancies and family history. Accepted for publication.

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