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Endogenous levels of prostaglandin F and its main metabolites in plasma and endometrium of normal and dysmenorrheic women

  • V. Lundström
    Correspondence
    Reprint requests: Viveca Lundström, M.D., Department of Obstetrics and Gynecology, Karolinska sjukhuset, 104 01 Stockholm, Sweden.
    Affiliations
    Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden

    Department of Chemistry, Karolinska Institutet Stockholm, Sweden.
    Search for articles by this author
  • K. Green
    Affiliations
    Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden

    Department of Chemistry, Karolinska Institutet Stockholm, Sweden.
    Search for articles by this author
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      Abstract

      The concentrations of prostaglandin F, 15-keto-13,14-dihydro-PGF, and 13,14-dihydro-PGF were determined in plasma and in endometrial specimens taken from both dysmenorrheic and normal women at the time of their menstruation. The estimations were carried out by means of the gas chromatography-mass spectrometry method. The plasma levels of 15-keto-13,14-dihydro-PGF in dysmenorrheic women ranged between 32 and 105 pg. per milliliter, which are significantly higher than the corresponding levels in eumenorrheic women, 20 to 33 pg. per milliliter. On the first day of menstrual bleeding the concentration of PGF in the endometrium was approximately 4 times higher (300 to 2,600 pg. per milligram) in cases of dysmenorrhea than in normal subjects. Treatment with either oral contraceptives or prostaglandin synthetase inhibitors lowered the concentrations significantly and the majority of patients became symptom free.
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