Advertisement

Effect of obesity on conversion of plasma androstenedione to estrone in postmenopausal women with and without endometrial cancer

  • P.C. MacDonald
    Correspondence
    Reprint requests: Dr. P. C. MacDonald, Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, Texas 75235.
    Affiliations
    Cecil H. and Ida Green Center for Reproductive Biology Sciences The University of Texas Southwestern Medical School Dallas, Texas USA.

    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical School Dallas, Texas USA.
    Search for articles by this author
  • C.D. Edman
    Affiliations
    Cecil H. and Ida Green Center for Reproductive Biology Sciences The University of Texas Southwestern Medical School Dallas, Texas USA.

    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical School Dallas, Texas USA.
    Search for articles by this author
  • D.L. Hemsell
    Affiliations
    Cecil H. and Ida Green Center for Reproductive Biology Sciences The University of Texas Southwestern Medical School Dallas, Texas USA.

    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical School Dallas, Texas USA.
    Search for articles by this author
  • J.C. Porter
    Affiliations
    Cecil H. and Ida Green Center for Reproductive Biology Sciences The University of Texas Southwestern Medical School Dallas, Texas USA.

    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical School Dallas, Texas USA.
    Search for articles by this author
  • P.K. Siiteri
    Affiliations
    Cecil H. and Ida Green Center for Reproductive Biology Sciences The University of Texas Southwestern Medical School Dallas, Texas USA.

    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical School Dallas, Texas USA.
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      The purpose of this study was to ascertain if a relationship exists between the transfer constant of conversion of plasma androstenedione to estrone ([ϱ]BUAE1) and total body weight or excessive body weight in 50 postmenopausal women, of whom 25 had adenocarcinoma of the endometrium and 25 had no endometrial disease. The [ϱ]BUAE1 ranged from 0.015 to 0.129 in these 50 women. The [ϱ]BUAE1 in the women with endometrial cancer was 0.051 ± 0.006 (mean ± S.E.), whereas that in the women with no endometrial disease was 0.039 ± 0.004. These values are not significantly different (p > 0.05). The body weights of these 50 women ranged from 104 to 430 pounds. The weight of the patients with endometrial cancer was 234 ± 16 pounds (mean ± S.E.), and that for the women with no endometrial disease was 194 ± 12 pounds. A statistically significant correlation (p < 0.001) was found between [ϱ]BUAE1 and body weight and between [ϱ]BUAE1 and excessive body weight in both groups of women. Moreover, obesity and aging appear to act in concert to potentiate the conversion of plasma androstenedione to estrone in extraglandular sites since the [ϱ]BUAE1 is considerably greater among obese postmenopausal women than among comparably obese premenopausal women.
      To read this article in full you will need to make a payment

      References

        • MacDonald P.C.
        • Siiteri P.K.
        Quantitation of estrogen production from circulating C19-precursors in non-pregnant subjects.
        in: ed. 3. International Congress Series No. 111. Excerpta Medica Foundation, Amsterdam1966: 151
        • MacDonald P.C.
        • Rombaut R.P.
        • Siiteri P.K.
        Plasma precursors of estrogen. I. Extent of conversion of plasma androstenedione to estrone in normal males and nonpregnant normal, castrate and adrenalectomized females.
        J. Clin. Endocrinol. Metab. 1967; 27: 1103
        • MacDonald P.C.
        • Grodin J.M.
        • Siiteri P.K.
        The utilization of plasma androstenedione for estrone production in women.
        in: ed. 3. International Congress Series No. 184. Excerpta Medica Foundation, Amsterdam1968: 770
        • MacDonald P.C.
        • Grodin J.M.
        • Siiteri P.K.
        Dynamics of androgen and oestrogen secretion.
        in: Baird D. Gonadal Steroid Secretion. ed. 3. Ciba Foundation Symposium. 1971: 158 (Edinburgh)
        • Siiteri P.K.
        • Hemsell D.L.
        • Edwards C.L.
        • MacDonald P.C.
        Estrogen and endometrial cardinoma.
        in: ed. 3. International Congress Series No. 273. Excerpta Medica Foundation, Amsterdam1972: 1231
        • Grodin J.M.
        • Siiteri P.K.
        • MacDonald P.C.
        Source of estrogen production in postmenopausal women.
        J. Clin. Endocrinol. Metab. 1973; 36: 207
        • Siiteri P.K.
        • MacDonald P.C.
        Role of extraglandular estrogen in human endocrinology.
        in: Greep R.O. Astwood E.B. Handbook of Physiology. American Physiological Society, Washington, D. C1973: 615 (sect. 7, Endocrinology)
        • Longcope C.
        Metabolic clearance and blood production rates of estrogens in postmenopausal women.
        Am. J. Obstet. Gynecol. 1971; 111: 778
        • MacDonald P.C.
        • Grodin J.M.
        • Edman C.D.
        • Vellios F.
        • Siiteri P.K.
        Origin of estrogen in a postmenopausal woman with a nonendocrine tumor of the ovary and endometrial hyperplasia.
        Obstet. Gynecol. 1976; 47: 644
        • Aiman J.
        • Nalick R.H.
        • Jacobs A.
        • Porter J.C.
        • Edman C.D.
        • Vellios F.
        • MacDonald P.C.
        The origin of androgen and estrogen in a virilized postmenopausal woman with bilateral benign cystic teratomas.
        Obstet. Gynecol. 1977; 49: 695
        • Southren A.L.
        • Olivo J.
        • Gordon G.G.
        • Vittek J.
        • Brener J.
        • Rafii F.
        The conversion of androgens to estrogens in hyperthyroidism.
        J. Clin. Endocrinol. Metab. 1974; 38: 207
        • Hemsell D.L.
        • Grodin J.M.
        • Brenner P.F.
        • Siiteri P.K.
        • MacDonald P.C.
        Plasma precursors of estrogen. II. Correlation of the extent of conversion of plasma androstenedione to estrone with age.
        J. Clin. Endocrinol. Metab. 1974; 38: 476
        • Gordon G.G.
        • Olivo J.
        • Rafii F.
        • Southren A.L.
        Conversion of androgens to estrogens in cirrhosis of the liver.
        J. Clin. Endocrinol. Metab. 1975; 40: 1018
        • Edman C.D.
        • MacDonald P.C.
        • Combes B.
        Extraglandular production of estrogen in subjects with liver disease.
        Gastroenterology. 1975; 69 (abstract): 819
        • MacDonald P.C.
        • Siiteri P.K.
        Relationship between extraglandular production of estrone and the occurrence of endometrial neoplasia.
        Gynecol. Oncol. 1974; 2: 2159
        • Edman C.D.
        • MacDonald P.C.
        The role of extraglandular estrogen in women in health and disease.
        in: James V.H.T. Serio M. Giusti G. The Endocrine Function of the Ovary. Academic Press, Inc, London1976: 135
        • Rizkallah T.H.
        • Tovell H.M.M.
        • Kelly W.G.
        Production of estrone and fractional conversion of circulating androstenedione to estrone in women with endometrial carcinoma.
        J. Clin. Endocrinol. Metab. 1975; 40: 1045
        • Siiteri P.K.
        The isolation of urinary estrogens and determination of their specific activities following the administration of radioactive precursors to humans.
        Steroids. 1963; 2: 687
        • Edman C.D.
        • Aiman E.J.
        • MacDonald P.C.
        Identification of the estrogen product of extragiandular aromatization of plasma androstenedione.
        Am. J. Obstet. Gynecol. 1978; 130: 439
        • Edman C.D.
        • MacDonald P.C.
        Effect of obesity on conversion of plasma androstenedione to estrone in ovulatory and anovulatory young women.
        Am. J. Obstet. Gynecol. 1978; 130: 456
        • Corscaden J.A.
        Cancer of the endometrium.
        in: Gynecologic Cancer. ed. 3. The Willimas & Wilkins Company, Baltimore1962 (Chap. 6)
        • Javert C.T.
        • Renning E.L.
        Endometrial cancer—survey of 610 cases treated at Women's Hospital (1919–1960).
        Cancer. 1963; 16: 1057
        • Lynch H.T.
        • Krush A.J.
        • Larsen A.L.
        • Magnuson C.W.
        Endometrial carcinoma: multiple primary malignancies, constitutional factors and heredity.
        Am. J. Med. Sci. 1966; 19: 381
        • Wynder E.L.
        • Escher G.C.
        • Mantel N.
        An epidemiological investigation of cancer of the endometrium.
        Cancer. 1966; 19: 489
        • Judd H.L.
        • Lucas W.E.
        • Yen S.S.C.
        Serum 17β-estradiol and estrone levels in postmenopausal women with and without endometrial cancer.
        J. Clin. Endocrinol. Metab. 1976; 43: 272
        • Hausknecht R.U.
        • Gusberg S.B.
        Estrogen metabolism in patients at high risk for endometrial carcinoma. II. The role of androstenedione as an estrogen precursor in postmenopausal women with endometrial carcinoma.
        Am. J. Obstet. Gynecol. 1973; 116: 981
        • Poortman J.
        • Thyssen J.H.H.
        • Schwartz F.
        Androgen production and conversion to estrogens in healthy postmenopausal women and in selected patients with breast cancer.
        J. Clin. Endocrinol. Metab. 1973; 37: 101
        • Schindler A.E.
        • Ebert A.
        • Friedrick E.
        Conversion of androstenedione to estrone by human fat tissue.
        J. Clin. Endocrinol. Metab. 1972; 5: 627
        • Bolt H.M.
        • Gobel P.
        Formation of estrogens from androgens by human subcutaneous adipose tissue in vitro.
        Horm. Metab. Res. 1972; 4: 312
        • Nimrod A.
        • Ryan K.J.
        Aromatization of androgens by human abdominal and breast fat tissue.
        J. Clin. Endocrinol. Metab. 1975; 40: 367
        • Edman C.D.
        • MacDonald P.C.
        Slow entry into blood of estrone produced in extraglandular sites in obesity and endometrial neoplasia.
        Gynecol. Invest. 1974; 5: 27
      1. MacDonald, P. C., Madden, J. D., Brenner, P. F., Wilson, J. D., and Siiteri, P. K.: Origin of estrogen in normal men and in women with testicular feminization. Submitted for publication.

        • Speert H.
        Endometrial cancer and hepatic cirrhosis.
        Cancer. 1949; 2: 597
        • Dunn L.J.
        • Bradbury J.T.
        Endocrine factors in endometrial carcinoma.
        Am. J. Obstet. Gynecol. 1967; 97: 465
      2. Aiman, E. J., Edman, C. D., Worley, R. J., Porter, J. C., Vellios, F., and MacDonald, P. C.: Androgen and estrogen formation in women with hyperthecosis, Obstet. Gynecol. In press.

        • Edman C.D.
        • Hemsell D.L.
        • Siiteri P.K.
        • MacDonald P.C.
        Origin and quantification of estrone production in women with endometrial neoplasia.
        Gynecol. Invest. 1975; 6: 23