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Serum anti-Escherichia coli antibodies and urinary β-glucuronidase for the diagnosis and control of evolution of urinary infection during pregnancy

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      Abstract

      Asymptomatic bacteriuria was found in 6.3 per cent of our patients. Prematurity was not found in treated asymptomatic bacteriuric or pyelonephritic patients. Urinary β-glucuronidase and serum antibodies against the O-antigen of Escherichia coli are higher than normal in 37 and 48 per cent, respectively, of asymptomatic bacteriuric patients. It has been demonstrated that high levels of urinary β-glucuronidase or serum antibodies are coincident with infection of the kidney; thus, one-third to one-half of the patients with asymptomatic bacteriuria are, in fact, clinically inapparent pyelonephritis, which can be detected through the estimation of urinary β-glucuronidase or serum antibodies. High levels of β-glucuronidase and antibodies were also found in 56 and 64 per cent, respectively, of pyelonephritic patients. Higher than normal antibody titers decrease after treatment; when the titers are low, they will probably remain steady.
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