“Gonadotropin-resistant ovaries” syndrome in association with secondary amenorrhea

  • Moon H. Kim
    Reprint requests: Dr. Moon H. Kim, Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, Illinois 60637
    Department of Obstetrics and Gynecology, Chicago Lying-in Hospital, University of Chicago, Pritzker School of Medicine, Chicago, Illinois, USA
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      Endocrinologic studies were done on a patient with “gonadotropin-resistant ovaries” syndrome presenting with secondary amenorrhea, increased secretion of gonadotropins, and unstimulated ovarian follicles. The feedback effects of estrogen upon the hypothalamic pituitary axis seemed to be present. Plasma levels of estradiol and estrone were in the low normal range. The levels of androgens in the plasma were slightly elevated, and the elevated levels appeared to be ovarian in origin. Clomiphene did not alter the levels of follicle-stimulating hormone (FSH) and luteinizing hormone significantly but increased the levels of estrone and estradiol. Histologic confirmation of unstimulated follicles and elevated levels of the gonadotropins, particularly FSH, are essential for diagnosis.
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