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Serum prolactin in patients with inappropriate lactation

  • David F. Archer
    Correspondence
    Reprint requests: Dr. David F. Archer, Magee-Womens Hospital, Forbes and Halket Streets, Pittsburgh, Pennsylvania, 15213.
    Affiliations
    Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Obstetrics and Gynecology, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, USA
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  • Howard R. Nankin
    Affiliations
    Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Obstetrics and Gynecology, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, USA
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  • Paul F. Gabos
    Affiliations
    Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Obstetrics and Gynecology, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, USA
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  • Joseph Maroon
    Affiliations
    Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Obstetrics and Gynecology, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, USA
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  • Steven Nosetz
    Affiliations
    Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Obstetrics and Gynecology, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, USA
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  • Saroj R. Wadhwa
    Affiliations
    Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Obstetrics and Gynecology, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, USA
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  • John B. Josimovich
    Affiliations
    Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Obstetrics and Gynecology, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, USA
    Search for articles by this author
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      Abstract

      Serum prolactin (HPRL) was evaluated with a specific double-antibody radioimmunoassay in 50 women with inappropriate lactation. The results allowed classification of patients on the basis of the basal prolactin values. Nineteen of the patients (38 per cent) had elevated serum HPRL values, and all 19 had amenorrhea. In this group there was increased incidence of endocrine dysfunction. In 31 patients (62 per cent), serum HPRL was normal, and in one half menstruation was occurring. It follows that elevated HPRL levels should be an indication for extensive investigation and follow-up. Synthetic thyroid-releasing factor was given to 6 selected individuals (5 with elevated basal HPRL levels). An exaggerated HPRL response was found in 3, and a poor response occurred in one of the patients tested. These findings appear to be related to the degree of pituitary reserve and hypothalmic control.
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