Advertisement

Studies of prolactin secretion in human pregnancy

  • J.E. Tyson
    Correspondence
    Reprint requests: Dr. J. E. Tyson, Dept. of Ob./Gyn., The Johns Hopkins University School of Medicine, 601 N. Broadway, Baltimore, Maryland 21205
    Affiliations
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA

    the McGill University Clinic, Royal Victoria Hospital Montreal, Quebec, Canada
    Search for articles by this author
  • P. Hwang
    Affiliations
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA

    the McGill University Clinic, Royal Victoria Hospital Montreal, Quebec, Canada
    Search for articles by this author
  • H. Guyda
    Affiliations
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA

    the McGill University Clinic, Royal Victoria Hospital Montreal, Quebec, Canada
    Search for articles by this author
  • H.G. Friesen
    Affiliations
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA

    the McGill University Clinic, Royal Victoria Hospital Montreal, Quebec, Canada
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Recent studies have confirmed the presence of a separate human prolactin (HPr) molecule. Measurement of HPr concentrations has been performed in normal and abnormal gestation and during the menstrual cycle. HPr rises throughout gestation with a return to prepregnant concentrations by the seventh postpartum day. Variable increases in plasma prolactin were observed after intravenous administration of arginine, especially after the thirtieth week of gestation. Puerperally, prolactin rises in response to suckling. Amniotic fluid prolactin levels are one hundred times those of maternal or fetal blood. No significant change in basal HPr is seen during the menstrual cycle. The ability to measure this new pituitary polypeptide by radioimmunoassay permits investigation of its role in human gestation.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Obstetrics & Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Frantz A.G.
        • Kleinberg D.L.
        Science. 1970; 170: 745
        • Rimoin D.L.
        • Holzman G.B.
        • Merimee T.J.
        • Rabinowitz D.
        • Barnes A.C.
        • Tyson J.E.
        • McKusick V.A.
        J. Clin. Endocrinol. 1968; 28: 1183
        • Tyson J.E.
        • Barnes A.C.
        • McKusick V.A.
        • Merimee T.J.
        J. Clin. Endocrinol. 1970; 31: 147
        • Hwang P.
        • Guyda H.J.
        • Friesen H.G.
        Ed. 1. Proc. Natl. Acad. Sci. U. S. A. 68. 1971: 1902
        • Guyda H.J.
        • Friesen H.G.
        Biochem. Biophys. Res. Commun. 1971; 42: 1068
        • Lewis U.L.
        • Singh N.P.
        • Seavey B.K.
        Biochem. Biophys. Res. Commun. 1971; 44: 1169
        • Roth J.
        • Glick S.M.
        • Yalow R.S.
        • Berson S.A.
        Science. 1963; 140: 897
        • Tyson J.E.
        • Jones G.
        • Huth J.
        • Thomas P.
        Am. J. Obstet. Gynecol. 1971; 109: 1080
        • Tyson J.E.
        • Merimee T.J.
        • Rabinowitz D.
        • Friesen H.
        Am. J. Obstet. Gynecol. 1969; 103: 313
        • Chard T.
        • Boyd N.R.H.
        • McNeilly A.S.
        • Landon S.
        J. Endocrinol. 1970; 48: 223
        • Linzell J.L.
        • Peaker M.
        Physiol. Rev. 1971; 51: 564
        • Friesen H.G.
        • Guyda H.J.
        • Hwang G.
        • Tyson J.E.
        • Barbeau A.
        J. Clin. Invest. 1972; (In press)
        • Horrobin D.F.
        • et al.
        Lancet. 1971; 2: 352
        • Tyson J.E.
        • Barnes A.C.
        • McKusick V.A.
        • Scott C.I.
        • Jones G.S.
        Am. J. Obstet. Gynecol. 1970; 108: 688
      1. Tyson, J. E., and Friesen, H. G.: Unpublished data.