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Full length article| Volume 113, ISSUE 1, P14-20, May 01, 1972

Studies of prolactin secretion in human pregnancy

  • J.E. Tyson
    Correspondence
    Reprint requests: Dr. J. E. Tyson, Dept. of Ob./Gyn., The Johns Hopkins University School of Medicine, 601 N. Broadway, Baltimore, Maryland 21205
    Affiliations
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA

    the McGill University Clinic, Royal Victoria Hospital Montreal, Quebec, Canada
    Search for articles by this author
  • P. Hwang
    Affiliations
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA

    the McGill University Clinic, Royal Victoria Hospital Montreal, Quebec, Canada
    Search for articles by this author
  • H. Guyda
    Affiliations
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA

    the McGill University Clinic, Royal Victoria Hospital Montreal, Quebec, Canada
    Search for articles by this author
  • H.G. Friesen
    Affiliations
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA

    the McGill University Clinic, Royal Victoria Hospital Montreal, Quebec, Canada
    Search for articles by this author
DOI:https://doi.org/10.1016/0002-9378(72)90446-2
Studies of prolactin secretion in human pregnancy
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      Abstract

      Recent studies have confirmed the presence of a separate human prolactin (HPr) molecule. Measurement of HPr concentrations has been performed in normal and abnormal gestation and during the menstrual cycle. HPr rises throughout gestation with a return to prepregnant concentrations by the seventh postpartum day. Variable increases in plasma prolactin were observed after intravenous administration of arginine, especially after the thirtieth week of gestation. Puerperally, prolactin rises in response to suckling. Amniotic fluid prolactin levels are one hundred times those of maternal or fetal blood. No significant change in basal HPr is seen during the menstrual cycle. The ability to measure this new pituitary polypeptide by radioimmunoassay permits investigation of its role in human gestation.
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      15. Tyson, J. E., and Friesen, H. G.: Unpublished data.

      Article Info

      Publication History

      Accepted: January 26, 1972
      Received: November 6, 1971

      Footnotes

      ☆This work was supported in part by United States Public Health Service Child Health and Human Development Grants HD 03830-03 and UD 01727-07 and by the Medical Research Council of Canada, Grant MA 2525.

      ☆☆Presented in part at the annual meeting of the Endocrine Society, San Francisco, California, 1971.

      Identification

      DOI: https://doi.org/10.1016/0002-9378(72)90446-2

      Copyright

      © 1972 Published by Elsevier Inc.

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