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Abstract
Recent studies have confirmed the presence of a separate human prolactin (HPr) molecule.
Measurement of HPr concentrations has been performed in normal and abnormal gestation
and during the menstrual cycle. HPr rises throughout gestation with a return to prepregnant
concentrations by the seventh postpartum day. Variable increases in plasma prolactin
were observed after intravenous administration of arginine, especially after the thirtieth
week of gestation. Puerperally, prolactin rises in response to suckling. Amniotic
fluid prolactin levels are one hundred times those of maternal or fetal blood. No
significant change in basal HPr is seen during the menstrual cycle. The ability to
measure this new pituitary polypeptide by radioimmunoassay permits investigation of
its role in human gestation.
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Tyson, J. E., and Friesen, H. G.: Unpublished data.
Article Info
Publication History
Accepted:
January 26,
1972
Received:
November 6,
1971
Footnotes
☆This work was supported in part by United States Public Health Service Child Health and Human Development Grants HD 03830-03 and UD 01727-07 and by the Medical Research Council of Canada, Grant MA 2525.
☆☆Presented in part at the annual meeting of the Endocrine Society, San Francisco, California, 1971.
Identification
Copyright
© 1972 Published by Elsevier Inc.