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Further studies on sperm-immobilizing antibody found in sera of unexplained cases of sterility in women

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      Abstract

      The sperm-immobilization test and Franklin-Dukes' and Kibrick's sperm-agglutination tests were compared as methods for detecting antisperm antibody in sera of sterile, pregnant, and unmarried women. Positive reactions in the sperm-immobilization test were given by sera of 17.2 per cent of the patients with sterility of unexplained cause and not by those of normal pregnant and unmarried women.
      Franklin-Dukes' and Kibrick's tests gave rather higher perceniages of positive sperm-agglutination reactions in normal pregnani women than in cases of sterility of unexplained cause but a very low percentage of positive reactions in unmarried women. The sperm-immobilizing factor found in sera of cases of sterility of unexplained cause were analyzed immunologically. This factor appeared to be an antibody. It was present in the γG and γM fractions, and in most cases it seemed to be an antibody against seminal plasma-specific antigens.
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