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Uterine vascular bed: Initial conductance and maximal vasodilator response

  • Frank C. Greiss Jr.
    Affiliations
    Section on Reproductive Biology, Department of Obstetrics and Gynecology, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA

    the Department of Physiology, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA

    Department of Community Medicine, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA
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  • Stephen G. Anderson
    Affiliations
    Section on Reproductive Biology, Department of Obstetrics and Gynecology, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA

    the Department of Physiology, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA

    Department of Community Medicine, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA
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  • George S. Malindzak Jr.
    Affiliations
    Section on Reproductive Biology, Department of Obstetrics and Gynecology, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA

    the Department of Physiology, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA

    Department of Community Medicine, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA
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  • A.Leonard Rhyne
    Affiliations
    Section on Reproductive Biology, Department of Obstetrics and Gynecology, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA

    the Department of Physiology, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA

    Department of Community Medicine, Bowman Gray School of Medicine of Wake Forest University Winston-Salem, North Carolina, USA
    Search for articles by this author
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      Abstract

      A range of initial vascular conductances (Ci) from 0.024 to 1.09 c.c. per minute per millimeter of mercury were induced in the uterine vascular beds of unanesthetized, castrated ewes by the daily injection of estradiol benzoate in sesame oil. The maximal conductance (Cm) evoked by a maximal dose of nitroglycerine (Ng) was determined at 85 different Ci levels in 15 ewes. Analysis of composite results and those in 12 individual ewes suggests a relationship between Cm and Ci described by the equation ln Cm = k ln Ci + α. This relationship indicates that the proportionate increase in conductance evoked by Ng with respect to the Ci progressively decreases as the Ci increases. The implications of these observations on uterine vascular research are discussed.
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