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Control of ovulation time with steroid and nonsteroid compounds

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      Abstract

      Steroid and nonteroid compounds were utilized in 352 patients in an attempt to regulate the time of ovulation in patients desiring to practice the thermosymptomatic method of family planning. The most effective hormonal agents were conjugated estrogens,
      Clomiphene citrate as Clomid was supplied by the Wm. S. Merrell Co., Cincinnati, Ohio.
      Clomiphene citrate as Clomid was supplied by the Wm. S. Merrell Co., Cincinnati, Ohio.
      0.1 mg., and clomiphene citrate,
      Premarin, 0.1 mg., was supplied by Ayerst Labs., New York, New York.
      Premarin, 0.1 mg., was supplied by Ayerst Labs., New York, New York.
      50 mg., in regimens explained. Ovulation control within 3 days was attained in 96.4 and 98.3 per cent, respectively, and unexpected premature or late ovulations were eliminated. The side reactions to conjugated estrogens, 0.1 mg., were virtually absent while those of clomiphene citrate were mild and transient. The concept of utilizing hormonal agents in perfecting the thermosymptomatic method of family planning is as valid as the use of steroid agents for contraceptive family planning.
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