Spontaneous abortion: Chromosome studies on 41 cases and an analysis of maternal age and duration of pregnancy in relation to karyotype

Peter Bowen; Catherine S.N. Lee

doi:10.1016/0002-9378(69)90688-7

Research Article| Volume 104, ISSUE 7, P973-983, August 01, 1969

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Spontaneous abortion

Chromosome studies on 41 cases and an analysis of maternal age and duration of pregnancy in relation to karyotype

Peter Bowen
Peter Bowen
Affiliations
Department of Pediatrics, the University of Alberta Edmonton, Alberta, Canada
University of Alberta Hospital Edmonton, Alberta, Canada
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Catherine S.N. Lee
Catherine S.N. Lee
Footnotes
Affiliations
Department of Pediatrics, the University of Alberta Edmonton, Alberta, Canada
University of Alberta Hospital Edmonton, Alberta, Canada
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Author Footnotes
∗ Medical Research Council Scholar.

DOI:https://doi.org/10.1016/0002-9378(69)90688-7

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Abstract

The relatively frequent occurrence of chromosomal abnormalities in spontaneous abortuses offers an opportunity to gain additional insight into the mechanisms and consequences of alterations in the karyotype. Studies on 41 successfully cultured specimens showed abnormalities belonging to each of the three major classes previously reported (autosomal trisomy, X-monosomy, and triploidy) as well as one case of mosaicism and one with a structural abnormality. Analyses of pooled data showed a higher mean maternal age and shorter mean period of gestation for trisomic abortuses than for abortuses associated with X-monosomy, triploidy, and normal chromosomes. No influence of maternal age could be demonstrated for X-monosomic or triploid abortions when these were compared with abortions having normal chromosomes. An association of triploidy with missed abortion was noted and may be significant.

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References

- Carr D.H.
Obst. & Gynec. 1965; 26: 308
- PubMed
- Google Scholar
- Kerr M.
- Rashad M.N.
Am. J. Obst. & Gynec. 1966; 94: 322
- Moorhead P.S.
- Nowell P.C.
- Mellmann W.J.
- Battips D.M.
- Hungerford D.G.
Exper. Cell Res. 1960; 20: 613
- Streeter G.L.
Contrib. Embryol. 1920; 55: 143
- Google Scholar
- Penrose L.S.
- Delhanty J.D.A.
Lancet. 1961; 1: 1261
- Delhanty J.D.A.
- Ellis J.R.
- Rowley P.T.
Lancet. 1961; 1: 1286
- Clendenin F.M.
- Benirschke K.
Lab. Invest. 1963; 12: 1281
- PubMed
- Google Scholar
- Thiede H.A.
- Salm S.B.
Am. J. Obst. & Gynec. 1964; 90: 205
- Hall B.
- Källén B.
Lancet. 1964; 1: 110
- Szulman A.E.
New England J. Med. 1965; 272: 811
- Sato H.
Lancet. 1965; 1: 1280
- Schlegel R.J.
- Neu R.L.
- Carneiro Leão J.
- Faréas Elvira
- Aspillaga M.J.
- Gardner L.I.
Cytogenetics. 1966; 5: 430
- Crossref
- Google Scholar
- Waxman S.H.
- Arakaki D.T.
- Smith J.B.
Pediatrics. 1967; 39: 425
- PubMed
- Google Scholar
- Edwards J.H.
- Yunchen C.
- Rushton D.I.
- Richards S.
- Mittwoch U.
Cytogenetics. 1967; 6: 81
(Geneva Conference)ed. 3. Cytogenetics. 5. 1966: 361
- Google Scholar
- Hamerton J.L.
- Giannelli F.
- Carter C.O.
Cytogenetics. 1963; 2: 194
- Bowen P.
- Lee C.S.N.
- Harvey J.C.
Am. J. M. Sc. 1968; 255: 368
- Singh R.P.
- Carr D.H.
Anat. Rec. 1966; 155: 369
- Haddad H.M.
- Wilkins L.
Pediatrics. 1959; 23: 885
- PubMed
- Google Scholar
- Wilkins L.
- Fleischman W.
J. Clin. Endocrinol. 1944; 4: 357
- Singh R.P.
- Carr D.H.
Obst. & Gynec. 1967; 29: 806
- PubMed
- Google Scholar
- Atkin N.B.
- Klinger H.P.
Lancet. 1962; 2: 727
- Makino S.
- Sasaki M.S.
- Fukuschima T.
Lancet. 1964; 2: 1273
- Penrose L.S.
Ann. New York Acad. Sc. 1954; 57: 494
- Smith D.W.
- Patau K.
- Therman E.
Lancet. 1961; 2: 211
- Hecht F.
- Bryant J.S.
- Motulski A.G.
- Giblett E.R.
J. Pediat. 1963; 63: 605
- Ferguson-Smith M.A.
- Mack W.S.
- Ellis P.M.
- Dickson M.
- Sanger R.
- Race R.R.
Lancet. 1964; 1: 46
- Boyer L.H.
- Ferguson-Smith M.A.
- Grumbach M.M.
Ann. Hum. Genet. 1961; 25: 215

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☆Aided by Grant MA 1568 from the Medical Research Council of Canada.

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DOI: https://doi.org/10.1016/0002-9378(69)90688-7

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