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Full length article| Volume 105, ISSUE 2, P257-268, September 15, 1969

Neuropsychological deficits in children of diabetic mothers

A report from the Collaborative Study of Cerebral Palsy
DOI:https://doi.org/10.1016/0002-9378(69)90067-2
Neuropsychological deficits in children of diabetic mothers
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      Abstract

      The question, whether maternal diabetes adversely affects intrauterine brain development as reflected in I.Q. of children, was studied prospectively. Complications of diabetes, such as severity (White's classification), acetonuria, insulin reaction, and prematurity, were studied. Subjects were matched with nondiabetic controls for hospital of birth, race, sex, socieconomic index, birth order, and maternal age. Diabetic mothers with acetonuria (N = 62) had offspring with lower I.Q. ( X ¯ = 93) than controls ( X ¯ = 102), (p < 0.001). However, the offspring of diabetic patients without acetonuria (N = 44) had I.Q. equal to their controls ( X ¯ = 101). The association between maternal diabetes complicated by acetonuria and I.Q. of the children was present in mild (including gestational) as well as in severe diabetes. No significant effect of insulin reactions in the mother on I.Q. of the offspring was demonstrated. The association of diabetes with acetonuria in respect to I.Q. of offspring was independent of duration of pregnancy.
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      References

        • Nocenti M.R.
        Endocrine Functions of the Pancreas.
        in: Bard P. Medical Physiology. ed. 11. The C. V. Mosby Company, St. Louis1961: 883-906
        • Quinto P.
        Minnesota Med. 1957; 58: 729
        • O'Sullivan J.B.
        New England J. Med. 1961; 26: 1082
        • Carrington E.R.
        • Messick R.R.
        Am. J. Obst. & Gynec. 1963; 85: 669
        • O'Sullivan J.B.
        • Gellis S.S.
        • Dandrow R.V.
        • Tenney B.O.
        Obst. & Gynec. 1966; 27: 683
        • Nonnis-Marzano C.
        • Palmarini O.
        Quad. clin. ostet. e ginec. 1963; 18: 1103
        • Moss J.M.
        • Mueholland H.B.
        Ann. Int. Med. 1951; 34: 678
        • Amici G.
        • Bailo U.
        • Samaia U.
        Minerva med. 1966; 57: 3755
        • Cappetti C.A.
        Minerva ginec. 1960; 12: 485
        • Carrington E.R.
        • Shuman C.R.
        • Reardon H.S.
        Obst. & Gynec. 1957; 9: 664
        • White P.
        Am. J. Med. 1949; 7: 609
        • Vaglio U.
        Arch. ostet. e ginec. 1952; 52: 313
        • Pezzali M.
        Quad. clin. ostet. e ginec. 1962; 17: 519
        • Massazza M.
        Atti Convegni. Amais. 1957; 2: 153
        • Given W.O.
        • Douglas R.G.
        • Tolstoi E.
        Am. J. Obst. & Gynec. 1950; 59: 729
        • Eastman N.J.
        Obst. & Gynec. Surv. 1946; 1: 3
        • Crenshaw C.
        • Parker R.T.
        • Carter B.
        Obst. & Gynec. 1962; 20: 334
        • Boronow R.C.
        • McElin T.W.
        Am. J. Obst. & Gynec. 1965; 91: 1022
        • Williger V.M.
        Am. J. Obst. & Gynec. 1966; 94: 57
        • Pedersen J.
        • Schondel A.
        Acta paediat. 1949; 77 (Suppl.): 203
        • Pedersen J.
        • Branstrup E.
        Lancet. 1959; 1: 606
        • Hubbell Jr., J.P.
        • Muirhead Jr., D.M.
        • Drorbaugh J.E.
        M. Clin. North America. 1965; 49: 1035
        • Pedersen J.
        • Pedersen L.M.
        Acta endocrinol. 1965; 50: 70
        • Pedersen J.
        Acta endocrinol. 1965; 50: 95
        • Lowrey G.H.
        • Graham B.D.
        • Tsao M.U.
        Pediatrics. 1954; 13: 527
        • Driscoll S.G.
        • Benirschke K.
        • Curtis G.W.
        Am. J. Dis. Child. 1960; 100: 818
        • Dekaban A.S.
        • Magee K.R.
        Neurology. 1958; 8: 193
        • Miller H.C.
        • Hurwitz D.
        • Kuder K.
        J. A. M. A. 1944; 124: 271
        • Von Mayer J.B.
        Bull. Schweiz. Akad. Med. Wiss. 1964; 20: 470
        • Miller H.C.
        Advances Pediat. 1956; 8: 137
        • Hagbard L.
        • Olow I.
        • Reinand T.
        Acta paediat. 1959; 48: 184
        • Hiekkala H.
        • Koskenoja M.
        Ann. paediat. Fenniae. 1961; 7: 17
        • Gellis S.
        • Hsia D.Y.
        Am. J. Dis. Child. 1952; 91: 1
        • Gleiss J.
        Monatsschr. Kinderheilk. 1965; 113: 278
        • Gordon H.H.
        Am. J. M. Sc. 1962; 244: 129
        • Farquhar J.W.
        Arch. Dis. Childhood. 1959; 34: 76
        • Jones W.S.
        Am. J. Obst. & Gynec. 1953; 66: 322
        • Shlevin E.L.
        • Pedowitz P.
        Pregnancy and Diabetes.
        in: Ellenberg M. Rifkin H. Clinical Diabetes Mellitus. McGraw-Hill Book Company, Inc, New York1962: 280-287
        • Wilkerson H.L.
        Am. J. Pub. Health. 1959; 49: 1032
        • Horger III, E.O.
        • Kellett III, W.W.
        • Williamson H.O.
        Obst. & Gynec. 1967; 30: 46
        • O'Sullivan J.B.
        • Mahan C.M.
        Diabetes. 1964; 13: 278
        • White P.
        • Gillespie L.
        • Sexton L.
        Am. J. Obst. & Gynec. 1956; 71: 57
        • Levinson S.A.
        • MacFate R.P.
        Chemical Analysis of the Urine.
        in: Levinson S.A. MacFate R.P. Clinical Laboratory Diagnosis. ed. 6. Lea & Febiger, Philadelphia1961: 543-610 (Chap. 11)

      44. Myrianthopoulos, N. C., and French, K. S.: Social Sc. & Med. In press.

        • Bayley N.
        Genet. Psychol. Monogr. 1933; 14 (Modified in 1958 for use in the Collaborative Perinatal Project, Perinatal Research Branch, National Institute of Neurological Diseases and Blindness, Bethesda, Maryland 20014): 1
        • Pedersen L.M.
        • Tygstrup I.
        • Pedersen J.
        Lancet. 1964; 1: 1124
        • Olsen B.R.
        • Osler M.
        • Pedersen J.
        Danish M. Bull. 1963; 10: 18
        • Takeuchi A.
        • Benirschke K.
        Biol. Neonat. 1961; 3: 237
        • Avery M.E.
        • Oppenheimer E.H.
        • Gordon H.H.
        New England J. Med. 1957; 256: 1134
        • Oppenheimer E.H.
        • Esterly J.R.
        J. Pediat. 1965; 67: 549
        • Hsia D.Y.Y.
        • Gellis S.S.
        Ann. Hum. Genet. 1954; 22: 186
        • Fee B.A.
        • Weil Jr., W.B.
        Ann. New York Acad. Sc. 1963; 110: 869
        • Osler M.
        Acta endocrinol. 1960; 34: 299
        • Kennan A.L.
        Am. J. Obst. & Gynec. 1962; 83: 515
        • Caldwell D.F.
        • Churchill J.A.
        Neurology. 1967; 17: 95

      Article Info

      Footnotes

      ☆The Collaborative Study of Cerebral Palsy, Mental Retardation and Other Neurological and Sensory Disorders of Infancy and Childhood is supported by the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Bethesda, Maryland. The following institutions participate: Boston Lying-In Hospital; Brown University; Charity Hospital, New Orleans; Children's Hospital of Buffalo; Children's Hospital of Philadelphia; Children's Medical Center, Boston; Columbia University; Johns Hopkins University; Medical College of Virginia; New York Medical College; Pennsylvania Hospital; University of Minnesota; University of Oregon; University of Tennessee; and the Perinatal Research Branch, NINDB, NIH.

      Identification

      DOI: https://doi.org/10.1016/0002-9378(69)90067-2

      Copyright

      © 1969 Published by Elsevier Inc.

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