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Placental site involution

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      Abstract

      The obliteration of the placental site post partum is accomplished by vascular constriction and occlusions giving hemostasis initially and a surface necrosis due to ischemia secondarily. Necrotic material is then sloughed into the endometrial cavity and cast from the uterus. After the slough, the area is restored by glandular epithelial cells growing in from the periphery and from the base. Although the reparative process is not unique, being similar to that found in other areas of the body after superficial injury and slough, the pattern of hyalinization of remaining vessels is unusual. Stigmas of vascular alteration remain for extended periods and appear to be characteristic of placental site involution.
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