Septic shock

Evaluation of the intradermal epinephrine test in diagnosis and of the effects of human plasma in potentiating coliform endotoxin
      This paper is only available as a PDF. To read, Please Download here.


      The presence of endotoxin in blood may be of critical importance in patients with septic shock. Douglas, Beller, and Debrovner1 suggested that necrosis following intradermal injection of epinephrine in rabbits given plasma from patients with septic shock denotes circulating endotoxin. In the present study only 2 of 15 rabbits gave positive intradermal tests after injection of serum from patients with endotoxin shock. Of 4 animals given serum from patients with gram-negative infection but no hypotension, one gave a positive intradermal test. No positive tests were encountered in the 10 controls. The study did not confirm that the intradermal epinephrine test was of value in patients with septic shock. The second part of this study confirmed that when endotoxin is mixed with human plasma, its toxic effect is significantly increased.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to American Journal of Obstetrics & Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Douglas G.W.
        • Beller Fritz K.
        • Debrovner C.H.
        Am. J. Obst. & Gynec. 1963; 87: 780