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Abstract
The presence of endotoxin in blood may be of critical importance in patients with
septic shock. Douglas, Beller, and Debrovner1 suggested that necrosis following intradermal injection of epinephrine in rabbits
given plasma from patients with septic shock denotes circulating endotoxin. In the
present study only 2 of 15 rabbits gave positive intradermal tests after injection
of serum from patients with endotoxin shock. Of 4 animals given serum from patients
with gram-negative infection but no hypotension, one gave a positive intradermal test.
No positive tests were encountered in the 10 controls. The study did not confirm that
the intradermal epinephrine test was of value in patients with septic shock. The second
part of this study confirmed that when endotoxin is mixed with human plasma, its toxic
effect is significantly increased.
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References
- Am. J. Obst. & Gynec. 1963; 87: 780
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© 1968 Published by Elsevier Inc.
