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Steroid synthesis in vitro by a hilar cell tumor

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      Abstract

      A 57-year-old woman with a 5 year history of progressive hirsutism and virilization was found at operation to have a hilar cell tumor in one ovary. Slices of the tumor were incubated separately in vitro with 3H-pregnenolone and 14C-progesterone. A high (7.5 and 7.2, respectively) percentage conversion of these precursors to testosterone was established. Labeled androstenedione, dehydroepiandrosterone, epitestosterone, and estrone were also found. The Δ5 pathway to androstenedione could well be dominant. Evidence for 11β-hydroxylation was obtained.
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