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Abstract
It has long been postulated that human female infertility might be due to an antisperm
antibody. Several methods were used to detect the antisperm antibody in the serum
of sterile women and it was demonstrated that the sperm immobilization test was the
best procedure. Three of 25 women with unexplained sterility showed a positive sperm
immobilization test. The sperm-immobilizing factor in patient's serum which gave the
strongest positive test was analyzed immunologically. This factor, which was present
in the γ-globulin fraction of serum, was not dialyzable. It displayed activity only
with complement and was specifically absorbed only by spermatozoa. After absorption
to spermatozoa, it was eluted by heat. 131I-labeled γ-globulin from the patient, absorbed onto sperm and eluted with heat, localized
more than twice as much on re-exposure to sperm than did absorbed and eluted 131I-γ-globulin from normal subjects.
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© 1968 Published by Elsevier Inc.
