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Prenatal serodiagnosis of blood group sensitization

II. Maternal sensitizations other than D(Rho), with a comparison of the red cell antigens Kell (K1), E(Rh″), and c(hr′)
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      Abstract

      All available prenatal sensitizations other than D (Rho) were examined by determining blood groups of all members in a pedigree; the newborn infants were studied for isoimmune erythroblastosis. The immune challenge responsible for the maternal sensitization was determined, and compatible blood for the mother and the infant was obtained in advance of delivery. Serologic types of erythroblastosis were detected that otherwise would have been unanticipated. Blood group sensitizations other than D (Rho) were compared in obstetric subjects and transfused male subjects. It is contended that the K (Kell) and E red cell antigens immunize persons chiefly through a series of incompatible transfusions and the c antigen through fetomaternal incompatible pregnancies—or rarely through both mechanisms. It is prudent transfusion practice to administer Kell- and E-compatible blood to patients lacking these antigens, especially to the multitransfused gravid woman.
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