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Ethacrynic acid (a new diuretic), pregnancy, and excessive fluid retention

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      Abstract

      A new nonthiazide oral diuretic, ethacrynic acid, was evaluated for safety and effectiveness in the treatment of 182 pregnant women suffering from pre-eclampsia and excessive fluid retention states. Salt intake was not restricted, minimal effective doses of the drug were used, and the method employed was that known, specifically, as intermittent diuretic therapy. Effectiveness was marked, as judged by loss of weight, improvement of edema and lowering of blood pressure. Reactions were similar to those of other diuretics, disappeared with continued use, and glycosuria was not encountered as a problem. There were no instances of teratogenesis, and ethacrynic acid is considered safe and effective for use during pregnancy.
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