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Comparison of the kinetics of clot formation, fibrinogen, fibrinolysis, and hematocrit in pregnant women and adults

  • Marguerite Markarian
    Footnotes
    Affiliations
    Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado, USA

    Department of Obstetrics, San Borja Hospital, University of Chile, Santiago, Chile
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  • Jacqueline J. Jackson
    Affiliations
    Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado, USA

    Department of Obstetrics, San Borja Hospital, University of Chile, Santiago, Chile
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  • Author Footnotes
    ∗ Dr. Markarian performed this study during the tenure of a United States Public Health Service Postdoctoral Research Fellowship. Present address: Mount Zion Hospital and Medical Center, Department of Pediatrics, 1600 Divisadero Street, San Francisco, California 94115.
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      Abstract

      Pregnant women in labor and adult controls were studied for differences in the kinetics of clot formation, using the thromboelastograph, a sensitive optical instrument which allows for a continuous recording of all phases of coagulation and gives information regarding the mechanical properties of the clot. Pregnant women were found to be significantly more hypercoagulable than adult controls. This hypercoagulability was further demonstrated by higher fibrinogen levels and less over-all fibrinolytic activity (longer fibrinolysis times) as compared to adult controls. Pregnant women in premature labor had higher fibrinogen levels and less fibrinolytic activity (longer fibrinolysis times) than those at term. The significances of these findings are discussed.
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      References

        • McKay D.G.
        ed. 3. Disseminated Intravascular Coagulation. An Intermediary Mechanism of Disease. Hoeber Medical Division, Harper & Row, Evanston, and London1965 (New York)
        • Hardaway R.M.
        • McKay D.G.
        Rev. Surg. 1963; 20: 297
        • Rodriguez-Erdmann F.
        New England J. Med. 1965; 273: 1370
        • Cegelski F.C.
        • DeWeese J.A.
        • Lund C.J.
        Am. J. Obst. & Gynec. 1964; 89: 510
        • Gollub S.
        • Ulin A.
        • Paxson N.F.
        • Winchell H.S.
        • O'Riordan J.
        • Back N.
        • Ambrus J.L.
        J. Lab. & Clin. Med. 1959; 53: 765
        • Reid D.E.
        • Weiner A.E.
        • Roby C.C.
        Am. J. Obst. & Gynec. 1953; 66: 465
        • Phillips L.L.
        • Montgomery Jr., G.
        • Taylor Jr., H.C.
        Am. J. Obst. & Gynec. 1957; 73: 43
        • Ratnoff O.D.
        • Vosburgh G.J.
        New England J. Med. 1952; 247: 970
        • McKay D.G.
        • Littlejohn Jr., T.W.
        • Schoenbucher A.K.
        Obst. & Gynec. 1955; 5: 85
        • Cope I.
        J. Obst. & Gynaec. Brit. Comm. 1964; 71: 112
        • Josey W.E.
        • Szeiklies G.
        J. A. M. A. 1963; 184: 164
        • Larrieu J.M.
        • Soulier J.P.
        • Minkowski A.
        Études neonatales. 1952; 1: 1
        • Davidson E.
        • Tomlin S.
        J. Clin. Path. 1963; 16: 112
        • Talbert L.M.
        • Langdell R.D.
        Am. J. Obst. & Gynec. 1964; 90: 44
        • Kasper C.E.
        • Hoag M.S.
        • Aggeler P.M.
        • Stone S.
        Obst. & Gynec. 1964; 24: 242
        • Pechet L.
        • Alexander B.
        New England J. Med. 1961; 265: 1093
        • Markarian M.
        • Lindley A.
        • Jackson J.J.
        • Bannon A.
        Thromb. & Diath. Haemorr. 1967; 17: 585
        • Ratnoff O.D.
        • Colopy J.E.
        • Pritchard J.A.
        J. Lab. & Clin. Med. 1954; 44: 408
        • Fresh J.W.
        • Ferguson J.H.
        • Lewis J.H.
        Obst. & Gynec. 1956; 7: 117
        • Eastman N.J.
        • Hellman L.N.
        Obstetrics.
        ed. 3. Meredith Publishing Company, New York1966
        • von Kaulla K.N.
        • Weiner M.
        Blood. 1955; 10: 362
        • Markarian M.
        • Githens J.H.
        • Jackson J.J.
        • Bannon A.
        • Lindley A.
        • Rosenblut E.
        • Martorell R.
        • Lubchenco L.O.
        Am. J. Dis. Child. 1967; 113: 312
        • Copley A.L.
        • Niewiarowski S.
        • Marechal J.
        J. Lab. & Clin. Med. 1959; 53: 468
        • Barter R.H.
        Am. J. Obst. & Gynec. 1964; 90 (discussion of Talbert, L. M., and Langdell, R. D.:): 49
        • Phillips L.L.
        • Skrodelis V.
        Pediatrics. 1958; 22: 715
        • deBastos M.
        • Srinivasan K.
        New York State J. Med. 1964; 64: 1119
        • McKenzie J.M.
        • Celander D.R.
        • Guest M.M.
        Am. J. Physiol. 1963; 204: 42
        • Hardaway R.M.
        • Johnson D.G.
        • Houchin D.N.
        • Jenkins E.B.
        • Burns J.W.
        • Jackson D.R.
        J. Trauma. 1964; 4: 673
        • Egeberg O.
        Scandinav. J. Clin. & Lab. Invest. 1962; 14: 230
        • Hartman M.M.
        California Med. 1963; 98: 27