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Endotoxin shock in the pregnant guinea pig

An evaluation of hyperbaric oxygen therapy
  • Denis Cavanagh
    Footnotes
    Affiliations
    Department of Obstetrics-Gynecology University of Miami School of Medicine, Jackson Memorial Hospital Miami, Florida, USA

    Department of Anesthesiology, University of Miami School of Medicine, Jackson Memorial Hospital Miami, Florida, USA
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  • Bradley E. Smith
    Affiliations
    Department of Obstetrics-Gynecology University of Miami School of Medicine, Jackson Memorial Hospital Miami, Florida, USA

    Department of Anesthesiology, University of Miami School of Medicine, Jackson Memorial Hospital Miami, Florida, USA
    Search for articles by this author
  • Author Footnotes
    ∗ Present address: Department of Obstetrics and Gynecology, St. Louis University School of Medicine, St. Louis, Missouri 63104.
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      Abstract

      Sixty-one pregnant guinea pigs were randomly divided into six study groups. These animals were subjected to various environmental conditions within a hyperbaric oxygen resuscitation chamber. About half of the animals were injected with coliform endotoxin. Hyperbaric oxygen apparently afforded no protection and the mortality was uniformly high in the endotoxin-injected groups of animals. There were no deaths in any of the control groups.
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