Amethopterin in the treatment of trophoblastic tumors

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      • 1.
        1. Three patients with histologically confirmed chorioadenoma destruens with extension and a patient with probable chorioadenoma were treated with amethopterin and all may be considered cured.
      • 2.
        2. Twelve patients with histologically proved choriocarcinoma with metastases were treated with amethopterin. Five after 3 years are clinically normal. These represent a 41 per cent 3 year salvage. Four patients with choriocarcinoma with metastases, after repeated courses of amethopterin treatment, have shown considerable improvement but still show residual lesions during a follow-up of 1 to 2 years. Three patients died from drug toxicity during the course of this 3 year study.
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