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Maternal blood and cerebrospinal fluid estimation following the administration of chloral hydrate during the puerperium

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      Abstract

      Twenty-five unselected puerperal patients were included in this study. The cerebrospinal fluid was obtained by lumbar puncture on the third postpartum day; blood was also obtained from the patient at the same time. The medication was administered in rectal suppositories, 1.2 Gm. Specimens were taken at intervals from 30 minutes following administration of the suppository to 10 hours and 30 minutes.
      The amounts of chloral hydrate and trichloroacetic acid in the cerebrospinal fluid were small. Urochloralic acid passes into the cerebrospinal fluid in substantial quantities. Exceptionally large quantities of urochloralic acid were demonstrated in Patients 3 and 6. These patients were suffering from severe pre-eclampsia with evidence of liver damage.
      The concentration of trichloroethanol in the cerebrospinal fluid is variable, but in general is less than that of either chloral hydrate or trichloroacetic acid.
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