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The treatment of pre-eclamptic edema with acetazoleamide (Diamox)

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      Abstract

      Diamox caused mild symptoms or signs in 4 patients (3 per cent). Since it is a sulfonamide, the possibility of precipitation in the kidney as well as leukopenia must be kept in mind.
      Diamox is a relatively safe drug for producing weight loss by increasing urine volume and urine sodium in pregnant patients with visible or occult edema (abnormal weight gain), pseudo-pre-eclampsia, hypertensive disease, and decompensated heart disease.
      Diamox has comparatively little effect on patients with true pre-eclampsia.
      The use of Diamox has some prognostic value in that a marked loss of weight due to a considerable increase in volume of urine and sodium excretion would suggest to us that the patient did not have pre-eclampsia-eclampsia but had water and electrolyte retention due to some other condition, possibly the pregnancy itself, multiple pregnancy, anemia, hypertensive disease, etc.
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