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The syndrome of testicular feminization in male pseudohermaphrodites

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      Abstract

      There is a clinically recognizable syndrome found in patients who are essentially normal-appearing women, but who have undescended testes in place of ovaries. The most significant features are:
      • 1.
        1. Female habitus, breast development, and other secondary sex characteristics.
      • 2.
        2. Scanty or absent axillary or pubic hair in most cases.
      • 3.
        3. Female external genitals, with a tendency to underdevelopment of labia, and a blind-ending vagina.
      • 4.
        4. Absence of internal genitals except for rudimentary anlage and for gonads which may be located intra-abdominally or along the course of the inguinal canal.
      • 5.
        5. Gonads histologically consistent with undescended testes.
      • 6.
        6. Urinary excretion studies have suggested such testes produce estrogen and androgen. Elevated urinary gonadotropins have also been found.
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