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Abstract
Progestin and estrogen therapy in abortion continues as a controversial issue. Laboratory
studies have failed to establish a deficiency of these hormones in the human being
as an important etiological factor in the spontaneous termination of early pregnancy.
Clinical investigations have accumulated a wide divergenece of opinions as to the
value of replacement therapy. Since recent observations have disclosed that the thermal
regulating mechanism of the body is directly influenced by progesterone and estrogen,
a clinical study of the oral basal temperature curve of patients with threatened and
inevitable abortion as well as ectopic pregnancy forms the basis of this study.
My study of the oral basal temperature curves of 425 women during normal pregnancy
is presented in a previous report. 1 In the event of pregnancy, the postovulatory temperature rise continues during the
first trimester. The corpus luteum regresses at the end of the third month of pregnancy
and it is at this time that the basal temperature elevation shows a gradual fall,
in most cases, so that the estrogen (preovulatory) level is attained by the fourth
or fifth month. Since the elevation of basal temperature due to progesterone is present
only during the first trimester of pregnancy, this affords an excellent indicator
of any significant metabolic changes occurring in threatened and inevitable abortion.
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References
- West. J. Surg. 1949; 57: 192
- J. M. Soc. New Jersey. 1942; 39: 333
- Obst. & Gynec. Survey. 1948; 3: 680
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© 1950 C. V. Mosby Company. Published by Elsevier Inc. All rights reserved.
