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Selective cytology smear for diagnosis of cancer

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      Abstract

      The selective cytology technique was developed in our search for a method of studying evidence of cancer growth in the cells which become earliest involved in cervical cancer.
      The squamous cells encircling the tiny cervical opening at the squamocolumnar junction constitute a key point of origin for cancer more frequently than any other single focus in the female body.
      The spatula test offers a technique providing “surface biopsy” information of these cells prior to their actual desquamation. (Other cytology techniques depend upon detection of cells already exfoliated into body secretions for cancer diagnosis).
      By study of these cells in selective cytology smears, morphologic changes have been identified believed to constitute a precancer cell-complex. Many of these so-called precancer cases have shown clinically normal cervices.
      Biopsies have verified suspicious nature of lesions.
      The selective cytology technique has been found to be more accurate as an indicator of endogenous estrogen by cornification counts in smears from the cervix and vagina in cancer cases. The previous aspiration method failed to reveal the true cornification level because of excessive amounts of blood and leucocytes obscuring the picture.
      Selective cytology may be used in the diagnosis of any accessible surface cancer, e.g., tongue, lip, throat, skin, and vulva, while cytological cancer diagnosis of other organs, e.g., stomach, lung, prostate, kidney, and bladder, must depend upon other cytology techniques recently developed.
      Through early diagnosis of cancer by routine cytology tests, death from cancer of the cervix should become highly preventable.
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      1. Ayre, J. E.: Awaiting publication.