American Journal of Obstetrics & Gynecology
Volume 179, Issue 4 , Pages 895-898 , October 1998

Relaxation of isolated human myometrial muscle by β2 -adrenergic receptors but not β1 -adrenergic receptors

Presented at the Eighteenth Annual Meeting of the Society of Perinatal Obstetricians, Miami Beach, Florida, February 2-7, 1998.

References 

  1. Lands AM, Arnold A, McAuliff JP, Ludena FP, Brown TG. Differentiation of receptor systems activated by sympathomimetic amines. Nature. 1967;214:597–598
  2. Hayashida DN, Leung R, Goldfien A, Roberts JM. Human myometrial adrenergic receptors: identification of the beta-adrenergic receptor by dihydroalprenolol binding. Am J Obstet Gynecol. 1982;142:389–393
  3. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Blochem. 1976;72:248–254
  4. Breuiller M, Rouot B, Leroy MJ, Blot P, Kaplan L, Ferre F. Adrenergic receptors in inner and outer layers of human myometrium near term: characterization of beta-adrenergic receptor sites by [125I]-iodocyanopindolol binding. Gynecol Obstet Invest. 1987;24:28–37
  5. Molenaar P, Summers RJ. Characterization of beta-1 and beta-2 adrenoceptors in guinea pig atrium: functional and receptor binding studies. J Pharmacol Exp Ther. 1987;241:1041–1047
  6. Bilski A, Dorries S, Fitzgerald JD, Jessup R, Tucker H, Wale J. ICI 118,551, a potent β2 adrenoceptor antagonist. Br J Pharmacol. 1979;292P–293P
  7. O’Donnell SR, Wanstall JC. Evidence that ICI 118,551 is a potent, highly beta2-selective adrenoceptor antagonist and can be used to characterize beta-adrenoceptor populations in tissues. Life Sci. 1980;27:671–677
  8. Phillipe M, Chien EK. Potassium chloride effects on the hormonal signal transduction mechanisms underlying myometrial contractions. J Endocrinol. 1995;146:485–493
  9. Jacobs MM, Hayashida D, Roberts JM. Human myometrial adrenergic receptors during pregnancy: identification of the alpha-adrenergic receptors by [3H] dihydroergocryptine binding. Am J Obstet Gynecol. 1985;152:680–684
  10. Berg G, Andersson RG, Ryden G. Alpha-adrenergic receptors in human myometrium during pregnancy. Am J Obstet Gynecol. 1986;154:601–606

☆ From the Departments of Pharmacology and Obstetrics and Gynecology, James H. Quillen College of Medicine, East Tennessee State University.

☆☆ Reprint requests: Peter J. Rice, PhD, ETSU Pharmacology, PO Box 70577, Johnson City, TN 37614-0577.

★ 0002-9378/98 $5.00 + 0   6/6/92536

PII: S0002-9378(98)70185-1

American Journal of Obstetrics & Gynecology
Volume 179, Issue 4 , Pages 895-898 , October 1998

Article Tools

* Image Usage & Resolution