American Journal of Obstetrics & Gynecology
Volume 176, Issue 5 , Pages 1026-1029, May 1997

Immunohistochemistry of vascular changes in leuprolide acetate–treated leiomyomas☆☆☆★★★

New York, New York

Received 4 October 1996; accepted 22 October 1996.

Abstract 

We report two cases of leuprolide acetate–treated leiomyomas with striking vascular changes and histologic features of vasculitis and atherosclerosis. These changes may cause ischemic damage if they occur in other organs. We describe the histologic findings and discuss their clinical implications. (Am J Obstet Gynecol 1997;176:1026-9.)

Keywords:  Leuprolide acetate, leiomyoma, vasculitis, atherosclerosis

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☆ From the Departments of Obstetric-Gynecologic Pathologyaand Obstetrics and Gynecologyband the Kaplan Cancer Center,cNew York University Medical Center, and the Department of Obstetrics and Gynecology, New York Infirmary–Beekman Downtown Hospital.d

☆☆ Supported by the Kaplan Cancer Center, National Cancer Institute grant No. P30 CA 16087.

★ Reprint requests: Augusto F. Mesia, MD, Obstetric-Gynecologic Pathology, New York University Medical Center, 550 First Ave., New York, NY 10016.

★★ 0002-9378/97 $ 5.00 + 06/1/78828

PII: S0002-9378(97)70397-1

American Journal of Obstetrics & Gynecology
Volume 176, Issue 5 , Pages 1026-1029, May 1997

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