American Journal of Obstetrics & Gynecology
Volume 203, Issue 6 , Pages 545.e1-545.e5 , December 2010

Oral contraceptives vs injectable progestin in their effect on sexual behavior

Presented in poster format at the Annual Meeting of the International Society for the Study of Women's Sexual Health, St. Petersburg, FL, Feb. 18-21, 2010.

Received 20 March 2010 ,Revised 7 June 2010 ,Accepted 20 July 2010.

References 

  1. Davis AR, Castano PM. Oral contraceptives and libido in women. Annu Rev Sex Res. 2004;15:297–320
  2. Schaffir J. Hormonal contraception and sexual desire: a critical review. J Sex Marital Ther. 2006;32:305–314
  3. Sanders SA, Graham CA, Bass JL, Bancroft J. A prospective study of the effects of oral contraceptives on sexuality and well-being and their relationship to discontinuation. Contraception. 2001;64:51–58
  4. Davis S. The clinical use of androgens in female sexual disorders. J Sex Marital Ther. 1998;24:153–163
  5. Panzer C, Wise S, Fantini G, et al. Impact of oral contraceptives on sex hormone-binding globulin and androgen levels: a retrospective study in women with sexual dysfunction. J Sex Med. 2006;3:104–113
  6. Alexander GM, Sherwin BB, Bancroft J, Davidson DW. Testosterone and sexual behavior in oral contraceptive users and non-users: a prospective study. Horm Behav. 1990;24:388–402
  7. Sarajari S, Wickman DS, Marin CM, Berman JR. Pilot study assessing the impact of hormonal contraceptives on serum testosterone levels and sexual function in pre-menopausal women. Fertil Steril. 2004;82(Suppl):S78–S79
  8. Bachmann G, Bancroft J, Braunstein G, et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril. 2002;77:660–665
  9. Jeppsson S, Gershagen S, Johansson ED, et al. Plasma levels of medroxyprogesterone acetate, sex-hormone binding globulin, gonadal steroids, gonadotrophins and prolactin in women during long-term use of depo-MPA (Depo-Provera) as a contraceptive agent. Acta Endocrinol. 1982;99:339–343(Copenh)
  10. Li RHW, Lo SST, Teh DKG, et al. Impact of common contraceptive methods on quality of life and sexual function in Hong Kong Chinese women. Contraception. 2004;70:474–482
  11. Matson SC, Henderson KA, McGrath GJ. Physical findings and symptoms of depot medroxyprogesterone acetate use in adolescent females. J Pediatr Adolesc Gynecol. 1997;10:18–23
  12. Rosen R, Brown C, Heiman J, et al. The Female Sexual Function Index: a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26:191–208
  13. ter Kuile MM, Brauer M, Laan E. The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS): psychometric properties within a Dutch population. J Sex Marital Ther. 2006;32:289–304
  14. Wiegel M, Meston C, Rosen R. The Female Sexual Function Index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther. 2005;31:1–20
  15. Davis SR, Davison SL, Donath S, Bell RJ. Circulating androgen levels and self-reported sexual function in women. JAMA. 2005;294:91–96
  16. Nyunt A, Stephen G, Gibbin J, et al. Androgen status in healthy premenopausal women with loss of libido. J Sex Marital Ther. 2005;31:73–80
  17. Greco T, Graham CA, Bancroft J, Tanner A, Doll HA. The effects of oral contraceptives on androgen levels and their relevance to premenstrual mood and sexual interest: a comparison of two triphasic formulations containing norgestimate and either 35 or 25 μg of ethinyl estradiol. Contraception. 2007;76:8–17
  18. Paul C, Skegg DCG, Williams S. Depot medroxyprogesterone acetate: patterns of use and reasons for discontinuation. Contraception. 1997;56:209–214
  19. Miller L, Patton DL, Meier A, Thwin SS, Hooten TM, Eschenbach DA. Depomedroxyprogesterone-induced hypoestrogenism and changes in vaginal flora and epithelium. Obstet Gynecol. 2000;96:431–439
  20. Graham CA, Ramos R, Bancroft J, Maglaya C, Farley TMM. The effects of steroidal contraceptives on the well-being and sexuality of women: a double-blind, placebo-controlled two-center study of combined and progestogen-only methods. Contraception. 1995;52:363–369
  21. Heiman JR, Meston CM. Evaluating sexual dysfunction in women. Clin Obstet Gynecol. 1997;40:616–629
  22. Clayton AH. Sexual function and dysfunction in women. Psychiatr Clin North Am. 2003;26:673–682

 Funded with a grant from Perinatal Resources Inc.

 Cite this article as: Schaffir JA, Isley MM, Woodward M. Oral contraceptives vs injectable progestin in their effect on sexual behavior. Am J Obstet Gynecol 2010;203:545.e1-5.

PII: S0002-9378(10)00908-7

doi: 10.1016/j.ajog.2010.07.024

American Journal of Obstetrics & Gynecology
Volume 203, Issue 6 , Pages 545.e1-545.e5 , December 2010

Article Tools