American Journal of Obstetrics & Gynecology
Volume 203, Issue 3 , Pages 246.e1-246.e4, September 2010

Association of midgestation paraoxonase 1 activity and pregnancies complicated by preterm birth

Presented at the 30th Annual Meeting of the Society for Maternal-Fetal Medicine, Chicago, IL, Feb. 1-6, 2010.

  • Arthur M. Baker, MD

      Affiliations

    • Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC
    • Corresponding Author InformationReprints: Arthur M. Baker, MD, Department of Obstetrics and Gynecology, University of North Carolina, 3010 Old Clinic Building, CB#7516, Chapel Hill, NC 27599-7516
    • ,
  • Sina Haeri, MD, MHSA

      Affiliations

    • Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC
    • ,
  • Richard L. Klein, PhD

      Affiliations

    • Division of Endocrinology, Metabolism, and Medical Genetics, Department of Medicine, Medical University of South Carolina, and Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC
    • ,
  • Kim Boggess, MD

      Affiliations

    • Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC

Received 8 February 2010; received in revised form 13 April 2010; accepted 29 April 2010. published online 14 June 2010.

Objective

The objective of the study was to determine whether an association exists between low paraoxonase 1 activity and dyslipidemia at midgestation and preterm birth.

Study Design

We conducted a case-control study of 30 women with preterm birth and 90 women with uncomplicated term deliveries. Maternal serum collected at 15-20 weeks was used to measure lipid concentrations and paraoxonase 1 activity using 2 substrates: paraoxon and phenylacetate (arylesterase activity).

Results

The groups did not differ with respect to maternal demographics. Paraoxonase 1 activity (paraoxon) was significantly lower in women delivering preterm compared with controls (12.9 ± 6.1 vs 16.6 ± 7.7 dA/min; P = .02). Arylesterase activity and serum lipid concentrations were similar between women with preterm birth and controls.

Conclusion

Midgestation paraoxonase 1 activity is lower in women who later experience spontaneous preterm birth compared with women who have term deliveries. Prospective studies are needed to determine the significance of paraoxonase 1 in the pathogenesis of preterm birth.

Key words: oxidative stress, paraoxonase 1, preterm birth

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 This study was supported in part by grants from the University of North Carolina Medical Alumni Endowment Fund (to A.M.B.), the North Carolina Translational and Clinical Sciences Institute (to A.M.B.), and a Department of Veterans Affairs MERIT award (to R.L.K.).

 Cite this article as: Baker AM, Haeri S, Klein RL, et al. Association of midgestation paraoxonase 1 activity and pregnancies complicated by preterm birth. Am J Obstet Gynecol 2010;203:246.e1-4.

PII: S0002-9378(10)00564-8

doi:10.1016/j.ajog.2010.04.048

American Journal of Obstetrics & Gynecology
Volume 203, Issue 3 , Pages 246.e1-246.e4, September 2010

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