American Journal of Obstetrics & Gynecology
Volume 203, Issue 3 , Pages 242.e1-242.e5 , September 2010

Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma

Presented at the Annual Meeting of the Society of Gynecologic Oncologists, San Antonio, TX, February 5-8, 2009.

  • Gloria S. Huang, MD

      Affiliations

    • Department of Obstetrics and Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Department of Molecular Pharmacology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Albert Einstein Cancer Center, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Corresponding Author InformationReprints: Gloria S. Huang, MD, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, 1695 Eastchester Rd., Suite 601, Bronx, NY 10461
    • ,
  • Marc J. Gunter, PhD

      Affiliations

    • Department of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • ,
  • Rebecca C. Arend, MD

      Affiliations

    • Department of Obstetrics and Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • ,
  • Maomi Li, MD, PhD

      Affiliations

    • Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • ,
  • Hugo Arias-Pulido, PhD

      Affiliations

    • Translational Therapeutics Laboratory, the University of New Mexico Cancer Center, Albuquerque, NM
    • ,
  • Eric R. Prossnitz, PhD

      Affiliations

    • Department of Cell Biology and Physiology, the University of New Mexico Cancer Center, Albuquerque, NM
    • ,
  • Gary L. Goldberg, MD

      Affiliations

    • Department of Obstetrics and Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Albert Einstein Cancer Center, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • ,
  • Harriet O. Smith, MD

      Affiliations

    • Department of Obstetrics and Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Albert Einstein Cancer Center, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY

Received 31 December 2009 ,Revised 27 April 2010 ,Accepted 28 April 2010.

References 

  1. Silverberg SG, Major FJ, Blessing JA, et al. Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: a gynecologic oncology group pathologic study of 203 cases. Int J Gynecol Pathol. 1990;9:1–19
  2. Amant F, Vloeberghs V, Woestenborghs H, et al. ERBB-2 gene overexpression and amplification in uterine sarcomas. Gynecol Oncol. 2004;95:583–587
  3. Yildirim Y, Inal MM, Sanci M, et al. Development of uterine sarcoma after tamoxifen treatment for breast cancer: report of four cases. Int J Gynecol Cancer. 2005;15:1239–1242
  4. Arenas M, Rovirosa A, Hernandez V, et al. Uterine sarcomas in breast cancer patients treated with tamoxifen. Int J Gynecol Cancer. 2006;16:861–865
  5. Huang GS, Chiu LG, Gebb JS, et al. Serum CA125 predicts extrauterine disease and survival in uterine carcinosarcoma. Gynecol Oncol. 2007;107:513–517
  6. Brandenberger AW, Tee MK, Lee JY, Chao V, Jaffe RB. Tissue distribution of estrogen receptors alpha (ER-alpha) and beta (ER-beta) mRNA in the midgestational human fetus. J Clin Endocrinol Metab. 1997;82:3509–3512
  7. Bardin A, Boulle N, Lazennec G, Vignon F, Pujol P. Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. Endocr Relat Cancer. 2004;11:537–551
  8. Yap OW, Bhat G, Liu L, Tollefsbol TO. Epigenetic modifications of the estrogen receptor beta gene in epithelial ovarian cancer cells. Anticancer Res. 2009;29:139–144
  9. Koehler KF, Helguero LA, Haldosén L-A, Warner M, Gustafsson J-A. Reflections on the discovery and significance of estrogen receptor beta. Endocr Rev. 2005;26:465–478
  10. Bulun SE. Endometriosis. N Engl J Med. 2009;360:268–279
  11. Trukhacheva E, Lin Z, Reierstad S, Cheng YH, Milad M, Bulun SE. Estrogen receptor (ER) beta regulates ERalpha expression in stromal cells derived from ovarian endometriosis. J Clin Endocrinol Metab. 2009;94:615–622
  12. Huang GS, Arend RC, Li M, et al. Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. Am J Obstet Gynecol. 2009;200:457.e1–457.e5
  13. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science. 2005;307:1625–1630
  14. Prossnitz ER, Maggiolini M. Mechanisms of estrogen signaling and gene expression via GPR30. Mol Cell Endocrinol. 2009;308:32–38
  15. Filardo EJ, Quinn JA, Bland KI, Frackelton AR. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol. 2000;14:1649–1660
  16. Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA, Hathaway HJ. Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol. 2008;70:165–190
  17. Smith HO, Leslie KK, Singh M, et al. GPR30: a novel indicator of poor survival for endometrial carcinoma. Am J Obstet Gynecol. 2007;196:386.e1–386.e11
  18. Filardo EJ, Graeber CT, Quinn JA, et al. Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression. Clin Cancer Res. 2006;12:6359–6366
  19. Smith H, Arias-Pulido H, Kuo D, et al. GPR30 predicts poor survival for ovarian cancer. Gynecol Oncol. 2009;114:465–471
  20. Plante BJ, Yuan L, Lessey BA, Young SL. Regulation and signaling of the membrane estrogen receptor, GPR30, in human endometrial cells. Reprod Sci. 2008;15:70A
  21. Hershberger PA, Stabile LP, Kanterewicz B, et al. Estrogen receptor beta (ERbeta) subtype-specific ligands increase transcription, p44/p42 mitogen activated protein kinase (MAPK) activation and growth in human non-small cell lung cancer cells. J Steroid Biochem Mol Biol. 2009;116:102–109
  22. Vivacqua A, Lappano R, De Marco P, et al. G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. Mol Endocrinol. 2009;23:1815–1826
  23. Albanito L, Sisci D, Aquila S, et al. Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells. Endocrinology. 2008;149:3799–3808
  24. Schipf A, Mayr D, Kirchner T, Diebold J. Molecular genetic aberrations of ovarian and uterine carcinosarcomas–a CGH and FISH study. Virchows Arch. 2008;452:259–268
  25. Pandey DP, Lappano R, Albanito L, Madeo A, Maggiolini M, Picard D. Estrogenic GPR30 signaling induces proliferation and migration of breast cancer cells through CTGF. EMBO J. 2009;28:523–532
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 Supported by the National Cancer Institute-National Institute of Child Health and Human Development Reproductive Scientist Development Program Grant 5K12HD000849, and the DEW Point Scholars Program, Department of Obstetrics and Gynecology and Women's Health at Albert Einstein College of Medicine (Dr Huang); and National Cancer Institute Grant CA118743 (Dr Prossnitz).

 Cite this article as: Huang GS, Gunter MJ, Arend RC, et al. Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma. Am J Obstet Gynecol 2010;203:242.e1-5.

PII: S0002-9378(10)00562-4

doi: 10.1016/j.ajog.2010.04.046

American Journal of Obstetrics & Gynecology
Volume 203, Issue 3 , Pages 242.e1-242.e5 , September 2010

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