American Journal of Obstetrics & Gynecology
Volume 203, Issue 3 , Pages 242.e1-242.e5, September 2010

Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma

Presented at the Annual Meeting of the Society of Gynecologic Oncologists, San Antonio, TX, February 5-8, 2009.

  • Gloria S. Huang, MD

      Affiliations

    • Department of Obstetrics and Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Department of Molecular Pharmacology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Albert Einstein Cancer Center, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Corresponding Author InformationReprints: Gloria S. Huang, MD, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, 1695 Eastchester Rd., Suite 601, Bronx, NY 10461
    • ,
  • Marc J. Gunter, PhD

      Affiliations

    • Department of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • ,
  • Rebecca C. Arend, MD

      Affiliations

    • Department of Obstetrics and Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • ,
  • Maomi Li, MD, PhD

      Affiliations

    • Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • ,
  • Hugo Arias-Pulido, PhD

      Affiliations

    • Translational Therapeutics Laboratory, the University of New Mexico Cancer Center, Albuquerque, NM
    • ,
  • Eric R. Prossnitz, PhD

      Affiliations

    • Department of Cell Biology and Physiology, the University of New Mexico Cancer Center, Albuquerque, NM
    • ,
  • Gary L. Goldberg, MD

      Affiliations

    • Department of Obstetrics and Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Albert Einstein Cancer Center, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • ,
  • Harriet O. Smith, MD

      Affiliations

    • Department of Obstetrics and Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY
    • Albert Einstein Cancer Center, Albert Einstein College of Medicine and Montefiore Medical Center; Bronx, NY

Received 31 December 2009; received in revised form 27 April 2010; accepted 28 April 2010. published online 04 June 2010.

Objective

We sought to evaluate the expression of G protein-coupled receptor 30 (GPR30) and estrogen receptor (ER)β in uterine carcinosarcoma (CS).

Study Design

Immunohistochemistry was performed using antibodies to GPR30, ERβ, ERα, and progesterone receptor (PR). The staining intensity and percentage of positive cells were scored for each tissue section. Expression levels were compared using the Wilcoxon rank sum test. Correlation was evaluated by Spearman rho and logistic regression.

Results

Compared with normal endometrium, CS had lower ERα and PR expression (both P < .01) but higher GPR30 epithelial expression (P = .03). Advanced-stage CS had higher GPR30 (P < .01) and ERβ (P = .02) epithelial expression compared with early-stage CS. Expression of GPR30 and ERβ correlated with each other (P < .01), and not with ERα or PR.

Conclusion

In uterine CS, GPR30 and ERβ are coordinately overexpressed and expression levels increase in advanced-stage disease, supporting the involvement of alternative ERs in disease progression.

Key words: estrogen receptor, G protein-coupled receptor 30, uterine carcinosarcoma

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 Supported by the National Cancer Institute-National Institute of Child Health and Human Development Reproductive Scientist Development Program Grant 5K12HD000849, and the DEW Point Scholars Program, Department of Obstetrics and Gynecology and Women's Health at Albert Einstein College of Medicine (Dr Huang); and National Cancer Institute Grant CA118743 (Dr Prossnitz).

 Cite this article as: Huang GS, Gunter MJ, Arend RC, et al. Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma. Am J Obstet Gynecol 2010;203:242.e1-5.

PII: S0002-9378(10)00562-4

doi:10.1016/j.ajog.2010.04.046

American Journal of Obstetrics & Gynecology
Volume 203, Issue 3 , Pages 242.e1-242.e5, September 2010

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